Fetal programming on adult hypertension in pregnant rats under hypercytokinaemia.

越来越多的人类流行病学研究证据表明，出生前发育不良与高细胞因子血症和成年后心血管疾病的发生有关。为探讨妊娠期高细胞因子血症对仔鼠出生后生长发育及血压的影响，采用脂多糖（LPS）或溶媒对妊娠期Wistar大鼠进行注射。从出生到8周龄，每周称重一次，并在16周龄时再次称重，还通过尾袖法测量了8周龄和16周龄的后代的血压和心率。8周龄仔鼠的收缩压、舒张压和平均血压分别为125.4±1.6、92.4±1.6和103.7±1.0mmHg。16周龄仔鼠血压分别为118.4±1.6、90.4±1.6和99.7±1.0（mmHg）。然而，我们不能测量这些数据在后代的高细胞因子血症，我们不能证明子女的高血压与高细胞因子血症的情况下，在怀孕。

Increasing evidence from human epidemiological studies suggests that poor growth before birth is associated with hypercytokinaemia and the development of cardiovascular disease in adulthood. Our objective was to investigate the effects of hypercytokinaemia during gestation in rats on postnatal growth and blood pressure of offsprings.Pregnant Wistar rats were injected LPS or vehicle. Offsprings were weighed weekly from birth until 8 weeks of age, and again at 16 weeks of age Blood pressure and heart rate were also measured in the offsprings at 8 and 16 weeks of age by the tail-cuff method. Data presented as mean±SE.In 8 week offsprings, systolic, diastolic and mean blood pressures (BP) were 125.4±1.6, 92.4±1.6 and 103.7±1.0mmHg, respectively. In 16 week offsprings, those blood pressures (BP) were 118.4±1.6, 90.4±1.6 and 99.7±1.0 (mmHg), respectively. However, we could not measure those data in offsprings under hypercytokinaemia.We could not demonstrate that hypertension of offsprings was related to hypercytokinaemia condition in pregnancy.