Fetal programming on adult hypertension in pregnant rats under hypercytokinaemia.

高细胞因子血症下妊娠大鼠成年高血压的胎儿编程。

• 批准号: 18591806
• 负责人: OKAWA Toshiaki
• 金额: $ 2.54万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591806/
• 关键词: Hypertension; inflammation; cytokine; fetal programming; environment in utero; fetus; adult; rat; 早産

Increasing evidence from human epidemiological studies suggests that poor growth before birth is associated with hypercytokinaemia and the development of cardiovascular disease in adulthood. Our objective was to investigate the effects of hypercytokinaemia during gestation in rats on postnatal growth and blood pressure of offsprings.Pregnant Wistar rats were injected LPS or vehicle. Offsprings were weighed weekly from birth until 8 weeks of age, and again at 16 weeks of age Blood pressure and heart rate were also measured in the offsprings at 8 and 16 weeks of age by the tail-cuff method. Data presented as mean±SE.In 8 week offsprings, systolic, diastolic and mean blood pressures (BP) were 125.4±1.6, 92.4±1.6 and 103.7±1.0mmHg, respectively. In 16 week offsprings, those blood pressures (BP) were 118.4±1.6, 90.4±1.6 and 99.7±1.0 (mmHg), respectively. However, we could not measure those data in offsprings under hypercytokinaemia.We could not demonstrate that hypertension of offsprings was related to hypercytokinaemia condition in pregnancy.

来自人类流行病学研究的越来越多的证据表明，出生前生长不良与高细胞动力学血症和成年后心血管疾病的发展有关。我们的目的是研究妊娠期高细胞活力血症对大鼠出生后生长和后代血压的影响。给妊娠Wistar大鼠注射LPS或对照物。从出生到8周龄，每周称重一次，16周龄时再次称重，并在8周龄和16周龄时用尾袖法测量血压和心率。数据以mean±SE表示。8周后，收缩压、舒张压和平均血压（BP）分别为125.4±1.6、92.4±1.6和103.7±1.0mmHg。16周子代血压（BP）分别为118.4±1.6、90.4±1.6和99.7±1.0 （mmHg）。然而，我们无法在高细胞运动血症的后代中测量这些数据。我们不能证明后代的高血压与妊娠期高细胞活力血症有关。

项目成果

Influence of progesterone on myometrial contractility in pregnant mice treated with LPS.

黄体酮对脂多糖处理的妊娠小鼠子宫肌层收缩力的影响。

• 发表时间: 2007
• 期刊: J Obstet Gynecol Res 33
• 作者: ANbe H;Okawa T;et al
• 通讯作者: et al

Nitric oxide and CD4+25+ regulatory T cell produotion〜

一氧化氮和 CD4+25+ 调节性 T 细胞的产生〜

• 发表时间: 2007
• 期刊: Word Congress of Perinatal Med
• 作者: H. Takahashi;T. Okawa
• 通讯作者: T. Okawa

Maternal regulation of high fat nourishment during lactation period reduce a hypertension of male offspring.

哺乳期母亲对高脂肪营养的调节可降低雄性后代的高血压。

• 发表时间: 2007
• 作者: Takahashi H;Okawa T;et al.
• 通讯作者: et al.

Prostaglandin E2 and nitric oxide production by paternal and maternal inherited iNOS in placental tissue in iNOS knocko ut mice treated with LPS.

在用 LPS 处理的 iNOS 敲除小鼠中，胎盘组织中父本和母本遗传的 iNOS 产生前列腺素 E2 和一氧化氮。

• 发表时间: 2007
• 作者: Takahashi H;Okawa T;et al.
• 通讯作者: et al.

Nitric oxide and CD4+25+ regulatory T cell production from iNOS knockout mice and their F1 mice treated with LPS.

iNOS 敲除小鼠及其用 LPS 处理的 F1 小鼠产生一氧化氮和 CD4 25 调节性 T 细胞。

• 发表时间: 2007
• 作者: Takahashi H;Okawa T
• 通讯作者: Okawa T