The Meanings of Galanin and Galanin Reseptors In Head and Neck Cancer

由于首席研究员的职位发生了变化，这项研究在爱知癌中心医院和爱知医科大学都进行了。2006 ~ 2007年采用免疫组织化学方法检测肝组织中甘丙肽受体1和甘丙肽受体2的表达。在2006年，从爱知癌症中心医院的舌癌手术患者中选择样本。2007年，从爱知医科大学手术的患者中选择了许多其他头颈癌的样本。（2006年研究结果）使用舌癌样本。使用的抗体由Gene Tex制造。Galanin受体1在正常组织中表达。而在肿瘤组织中，甘丙肽受体1的表达很少。对于甘丙肽受体2，在正常或肿瘤组织中均未观察到表达。（2007年结果）研究在爱知医科大学进行。使用的抗体由Alpha Diagnostic制造。在正常组织中， 关于我们 可见甘丙肽受体1和2。而在肿瘤组织中，甘丙肽受体1的表达降低。甘丙肽受体2的表达非常强。此外，使用腮腺恶性肿瘤标本进行检查。首次证实Galanin受体1和2在腮腺组织中表达。我们集中在一个混合的情况下样本的恶性程度较低的病变和高度恶性病变。在恶性程度较低的病变中，甘丙肽受体1的表达高于甘丙肽受体2。另一方面，在高度恶性病变中，甘丙肽受体1的表达低于甘丙肽受体2。（讨论）我们最初假设甘丙肽受体1作为肿瘤抑制基因，甘丙肽受体2作为癌基因。这种差异和分布来源于不同G蛋白偶联的信号转导差异。从2007年的研究结果来看，甘丙肽受体1将能够作为抑癌基因发挥作用，而甘丙肽受体2将作为癌基因发挥作用。看来今后有必要作进一步审查。少

This research was done both in Aichi Cancer Center Hospital and Aichi Medical University because the head investigator changed his position. During 2006 to 2007, the expressions of Galanin receptor 1 and Galanin receptor 2 were examined using immunohistochemical technique. In 2006, samples were selected from those operated for tongue cancer at Aichi Cancer Center Hospital. On 2007, the samples of many other head and neck cancers were selected from patients operated at Aichi Medical University. (Results of 2006 research) Tongue cancer samples were used. The antibodies used were made by Gene Tex. The expression of Galanin receptor 1 was seen in normal tissue. However, in the tumor tissue, the expression of Galanin receptor 1 was rarely seen. For Galanin receptor 2, the expression was not seen in either normal or tumor tissue. (Results of 2007) The research was done in Aichi Medical University. The antibodies used were made by Alpha Diagnostic. In the normal tissue, both the expression of … More Galanin receptor 1 and 2 were seen. However, in the tumor tissue, the expression of Galanin receptor 1 was decreased. The expression Galanin receptor 2 was very strong. In addition, the parotid malignant tumor specimen was used and examined. The expressions of Galanin receptor 1 and 2 were confirmed in the parotid tissue for the first time. We focused on a mixed case sample of a less malignant lesion and a highly malignant lesion. In the less malignant lesion, the expression of Galanin receptor 1 was higher than that of Galanin receptor 2. On the other hand, in the highly malignant lesion, the expression of Galanin receptor 1 was lower than that of Galanin receptor 2.(Discussion) We originally assumed that Galanin receptor 1 worked as a tumor suppressor gene and Galanin receptor 2 as an oncogene. This difference and distribution derive from the signal transduction differences from the different G-protein coupling. From the results of 2007 research, Galanin receptor 1 will be able to work as a tumor suppressor gene, and Galanin receptor 2 as an oncogene. It seems that a further examination is necessary in the future. Less