An experimental study on the motility of rectal branches in the pelvic plexus during bowel movement

排便时盆腔丛直肠支运动的实验研究

• 批准号: 18591960
• 负责人: KOHNO Miyuki
• 金额: $ 2.57万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591960/
• 关键词: colonic motility; Hirschsprung's disease; defecation; parasympathetic nerve; 小児外科; 骨盤神経

The rectal branches of the nerve arising from the pelvic plexus are divided into two : the parasympathetic nerves ascending along the sigmoid, and the intramural ascending nerve. It has not been fully revealed how these branches are involved in bowel movement. We studied the motility of rectal branches in the pelvic plexus that are involved in bowel movements using radical surgical models for Hirschsprung's disease.【Materials and Methods】The colonic motility on defecation was measured by using four strain gauge force transducers (SGT) in four groups of Beagle dogs: including a control group, a Neurotomy group, a transanal Soave procedure (TAS) group and an open Soave procedure (OS) group. In the Neurotomy and OS group, the parasympathetic nerve ascending along the sigmoid of the rectal branches of the nerve arising from the pelvic plexus was cut and then the intramural ascending nerve was cut. In the TAS group, the parasympathetic nerve ascending along the sigmoid of the rectal branche … More s of the nerve arising from the pelvic plexus was intact and then the intramural ascending nerve was cut.【Results】The control group had high amplitude contraction soon after the relaxation wave with defecation at 5 cm to the oral side SGT from reflection of peritoneum and a relaxation wave with defecation in SGT of reflection of the peritoneum. The Neurotomy and OS had no high amplitude contraction and no relaxation wave with defecation. The TAS had no relaxation wave and high amplitude contraction with defecation and an atypical relaxation wave with defecation above the pulled-through anastomosis.【Conclusions】Theses results, suggest that the relaxation wave with defecation may be related to the mesenteric nerve arising from pelvic plexus. The TAS preserved the parasympathetic nerve ascending along the sigmoid, but there was no high amplitude contraction on defecation. These results did not show any advantage of TAS regarding colonic motility on defecation. It was indicated that the rectal branches of the pelvic plexus plays an important role in lower colon motility as well as in bowel movement. Less

从盆丛发出的神经的直肠分支分为两个：副交感神经和壁内升神经，副交感神经沿着乙状结肠上行。目前还没有完全揭示这些分支如何参与排便。我们利用先天性巨结肠根治性手术模型研究了盆丛直肠支的运动，这些直肠支参与排便。【材料与方法】采用4个应变式力传感器（strain-gauge force transducer，SGT）对4组Beagle犬（对照组、神经切断组、经肛门Soave术（transanal Soave procedure，TAS）组和开放式Soave术（open Soave procedure，OS）组）排便时的结肠运动进行测量。在神经切断术和OS组中，切断沿着从盆丛发出的神经的直肠分支的乙状结肠上行的副交感神经，然后切断壁内上行神经。TAS组副交感神经沿着乙状结肠直肠支上行 ...更多信息 在保留盆丛神经的基础上，切断盆丛肌壁内上行神经。[结果]对照组在腹膜反射距口侧SGT 5cm处出现排便舒张波后不久即出现高幅收缩，腹膜反射SGT处出现排便舒张波后不久即出现高幅收缩。神经切断术和OS均无随排便而出现的高振幅收缩波和舒张波。TAS无舒张波，排便时有高幅度收缩，在牵拉吻合口上方排便时有非典型舒张波。[结论]排便时的舒张波可能与盆丛发出的肠系膜神经有关。TAS保留了副交感神经沿乙状结肠沿着上行，但排便时无高幅度收缩。这些结果未显示TAS在排便时结肠运动方面的任何优势。表明盆丛直肠支在低位结肠运动和排便中起重要作用。少