Analysis of entire physiological roles of mammalian mtDNA by generation of mice carrying various pathogenic mutations

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In this project we showed that specific pathogenic mutations that induce significant ROS production induced highly metastatic potentials in tumor cells. Moreover, when we introduced one of them into female germlines, and generated mito-mice with the mutation, mito-mice expressed diabetes and lymphoma development. On the contrary, we also found novel roles of specific polymorphic mtDNA mutations, which can be recognized and excluded by innate immune systems.