Translational research on novel peptides in veterinary and livestock science

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Canine and cattle ghrelin were purified and identified. The canine ghrelin was very effective for anorexia in companion animals, and this effect was applied to international patent. We discovered that the des-acyl ghrelin resulted in decrease of body temperature and this action had therapeutic value for heatstroke during summer in cattle(international patent application). Treatment with cattle ghrelin significantly increased milk yield in daily cattle. In addition, we clarified the many novel physiological functions of neuromedin S, such as antidiuresis. We produced Daruma mice on the C57BL/6J background, and showed that Daruma mice exhibited unique characteristics and may be a good model for studying human metabolic syndrome and antidiabetic drug.