Translational research on novel peptides in veterinary and livestock science

对犬和牛ghrelin进行了纯化和鉴定。犬ghrelin对伴侣动物厌食症非常有效，该效果已申请国际专利。我们发现，去酰基生长素释放肽导致体温下降，这一作用对牛夏季中暑具有治疗价值（国际专利申请）。用牛胃促生长素治疗显着增加了奶牛的日产奶量。此外，我们还阐明了神经介素S的许多新的生理功能，例如抗利尿作用。本研究以C57 BL/6 J小鼠为基础，建立了Daruma小鼠的动物模型，证明Daruma小鼠具有独特的生物学特性，是研究人类代谢综合征和抗糖尿病药物的良好模型。

Canine and cattle ghrelin were purified and identified. The canine ghrelin was very effective for anorexia in companion animals, and this effect was applied to international patent. We discovered that the des-acyl ghrelin resulted in decrease of body temperature and this action had therapeutic value for heatstroke during summer in cattle(international patent application). Treatment with cattle ghrelin significantly increased milk yield in daily cattle. In addition, we clarified the many novel physiological functions of neuromedin S, such as antidiuresis. We produced Daruma mice on the C57BL/6J background, and showed that Daruma mice exhibited unique characteristics and may be a good model for studying human metabolic syndrome and antidiabetic drug.