Modulation of cellular metabolism based on controlling the mobility of multivalent ligands using stimuli-responsive polyrotaxanes
Modulation of cellular metabolism based on controlling the mobility of multivalent ligands using stimuli-responsive polyrotaxanes
批准号:
19300170
负责人:
YUI Nobuhiko
金额:
$10.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010
中文摘要
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英文摘要
In order to aim at controlling cellular response via stimuli-responsive polyrotaxanes, the preparation of a variety of polyrotaxanes, the characterization of their properties, and the protein and cellular responses to these polyrotaxanes were performed. Macromolecular inclusion of loose-fit polyrotaxane, temperature-responsive polyrotaxane formation, enhanced binding of mannose-conjugated polyrotaxane with specific protein, and the production of anti-inflammatory cytokine from macrophages were clarified in this study.
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Supramolecular mobility in polyrotaxanes exploits biomedical functions
聚轮烷的超分子流动性利用生物医学功能
DOI:
--
发表时间:
2009
期刊:
Macromolecular Symposia 279
影响因子:
--
作者:
[T. Niidome, A. Ohga, Y. Niidome, T. Mori, Y. Katayama, 由井伸彦]
通讯作者:
由井伸彦
Polyrotaxane composed of poly-L-lactide and alpha-cyclodextrin exhibiting protease triggering hydrolysis
由聚-L-丙交酯和α-环糊精组成的聚轮烷表现出蛋白酶触发水解
DOI:
--
发表时间:
2009
期刊:
Biomacromolecules 10
影响因子:
--
作者:
[Y.Ohya, S.Takamido, K.Nagahama, T.Ouchi, R.Katoono, 由井伸彦]
通讯作者:
由井伸彦
バイオマテリアルとしての動的表面設計
作为生物材料的动态表面设计
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Isoda, K., Kagaya, N., Akamatsu, S., Hayashi, S., Tamesada, M., Watanabe, A., Kobayashi, M., Tagawa, Y., Kondoh, M., Kawase, M., Yagi, K., 由井伸彦]
通讯作者:
由井伸彦
PEGとγ-CDからなる1分子鎖"すかすか"ポリロタキサン
由PEG和γ-CD组成的单分子链“sukasuka”聚轮烷
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[高橋明裕, 上遠野亮, 由井伸彦]
通讯作者:
由井伸彦
Azidated polyrotaxanes for facile and efficient functionalization via clickchemistry
叠氮化聚轮烷通过点击化学实现轻松高效的官能化
DOI:
--
发表时间:
2011
期刊:
Macromolecuclar Rapid Communications
影响因子:
--
作者:
[H.Hyun, N.Yui]
通讯作者:
N.Yui
共 33 条
Interfacial adhesion and deadhesion by velcro-like entanglement controls of grafted polymer chains under biological environment
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批准号:16K12893
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.25万
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财政年份:2016
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负责人:YUI Nobuhiko
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依托单位:
Supramolecular scaffolds with molecular mobility for periodontal tissue regeneration
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批准号:16H01852
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$28.12万
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财政年份:2016
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负责人:YUI Nobuhiko
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依托单位:
Design of supramolecular ligands that can multivalently interact with receptor proteins on cellular membranes
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批准号:14380397
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.15万
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财政年份:2002
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负责人:YUI Nobuhiko
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依托单位:
Design of Hyaluronic Acids Hydrogels as a Long-term Implant and Those Application for Endometriosis Therapy
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批准号:13558106
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.63万
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财政年份:2001
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负责人:YUI Nobuhiko
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依托单位:
Design of drug carriers based on biodegradable polyrotaxanes
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批准号:09480253
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.13万
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财政年份:1997
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负责人:YUI Nobuhiko
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依托单位:
海外基金