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Modulation of cellular metabolism based on controlling the mobility of multivalent ligands using stimuli-responsive polyrotaxanes

Modulation of cellular metabolism based on controlling the mobility of multivalent ligands using stimuli-responsive polyrotaxanes
基于使用刺激响应性聚轮烷控制多价配体的迁移率来调节细胞代谢
批准号:
19300170
负责人:
YUI Nobuhiko
金额:
$10.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010

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中文摘要
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英文摘要
In order to aim at controlling cellular response via stimuli-responsive polyrotaxanes, the preparation of a variety of polyrotaxanes, the characterization of their properties, and the protein and cellular responses to these polyrotaxanes were performed. Macromolecular inclusion of loose-fit polyrotaxane, temperature-responsive polyrotaxane formation, enhanced binding of mannose-conjugated polyrotaxane with specific protein, and the production of anti-inflammatory cytokine from macrophages were clarified in this study.
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会议论文
Supramolecular mobility in polyrotaxanes exploits biomedical functions
聚轮烷的超分子流动性利用生物医学功能
DOI: --
发表时间: 2009
期刊: Macromolecular Symposia 279
影响因子: --
作者: [T. Niidome, A. Ohga, Y. Niidome, T. Mori, Y. Katayama, 由井伸彦]
通讯作者: 由井伸彦
Polyrotaxane composed of poly-L-lactide and alpha-cyclodextrin exhibiting protease triggering hydrolysis
由聚-L-丙交酯和α-环糊精组成的聚轮烷表现出蛋白酶触发水解
DOI: --
发表时间: 2009
期刊: Biomacromolecules 10
影响因子: --
作者: [Y.Ohya, S.Takamido, K.Nagahama, T.Ouchi, R.Katoono, 由井伸彦]
通讯作者: 由井伸彦
バイオマテリアルとしての動的表面設計
作为生物材料的动态表面设计
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Isoda, K., Kagaya, N., Akamatsu, S., Hayashi, S., Tamesada, M., Watanabe, A., Kobayashi, M., Tagawa, Y., Kondoh, M., Kawase, M., Yagi, K., 由井伸彦]
通讯作者: 由井伸彦
PEGとγ-CDからなる1分子鎖"すかすか"ポリロタキサン
由PEG和γ-CD组成的单分子链“sukasuka”聚轮烷
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [高橋明裕, 上遠野亮, 由井伸彦]
通讯作者: 由井伸彦
33
    Interfacial adhesion and deadhesion by velcro-like entanglement controls of grafted polymer chains under biological environment
    • 批准号:
      16K12893
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.25万
    • 财政年份:
      2016
    • 负责人:
      YUI Nobuhiko
    • 依托单位:
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    • 批准号:
      16H01852
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $28.12万
    • 财政年份:
      2016
    • 负责人:
      YUI Nobuhiko
    • 依托单位:
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