Novel antimicrobial target discovery by an integrated approach.

通过综合方法发现新的抗菌靶点。

• 批准号: LP150100137
• 负责人: Prof Yaoqi Zhou
• 金额: $ 16.67万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-09-28 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP150100137
• 关键词: Novel; antimicrobial; target; discovery; integrated

The project aims to uncover the molecular targets of BDM-I, a novel antimicrobial candidate discovered by the start-up Australian company BioDiem Ltd. BDM-I is active against many drug resistant bacterial and fungal microorganisms and it is currently in pre-clinical development. However, the lack of resistant phenotypes makes it difficult to identify BDM-I’s mechanism of action. The project plans to use an integrated approach that combines a novel technique of in silico screening with experimental validation. Project outcomes are anticipated to include the first computational method to integrate target and ligand similarity for proteome-scale target and off-target discovery, which will advance the global fight against drug-resistant microorganisms.

该项目旨在揭示BDM-I的分子靶点，BDM-I是澳大利亚初创公司BioDiem Ltd.发现的一种新型抗菌候选物，BDM-I对许多耐药细菌和真菌微生物具有活性，目前正处于临床前开发阶段。然而，由于缺乏耐药表型，很难确定BDM-I的作用机制。该项目计划使用一种综合方法，将一种新的计算机筛选技术与实验验证相结合。项目成果预计将包括第一个整合目标和配体相似性的计算方法，用于蛋白质组规模的目标和脱靶发现，这将推动全球对抗耐药微生物的斗争。