Translation arrest and degradation of aberrant protein induced by translation of poly(A) tail

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Gene expression is highly accurate due to quality-control systems that prevent the expression of potentially harmful protein products. We previously reported that translation of the poly(A) tail plays a crucial role in repressing the production of aberrant proteins from nonstop mRNAs by both translation repression and proteasome-dependent nascent protein destabilization in yeast. This clearly indicates that translation arrest and protein degradation, in addition to mRNA degradation, are crucial for repressing the expression of nonstop mRNAs. We also recently reported that translation arrest caused by the presence of consecutive basic amino acids in a nascent protein induces Not4p-dependent co-translational protein degradation by the proteasome.