Relationship between metabolic conversion of dietary flavonoids and their functions on oxidative stress

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This study was aimed to clarify the relationship between metabolic conversion of dietary flavonoids and their functions on oxidative stress control using quercetin, an antioxidative flavonoid ubiquitously present in fruits nad vegetables. The results indicate that conjugated quercetin metabolites exert a powerful antioxidant activity after deconjugation via activated macrophage-like cells. It is likely that dietary flavonoids are helpful in the suppression of oxidatives stress occurring in the target sites of intima and CNS by converting to their aglyone under stress-loaded state.