Development of reproductive biology by analysis of oocyte-producing male mouse strain

通过分析产生卵母细胞的雄性小鼠品系来发展生殖生物学

• 批准号: 19380162
• 负责人: KON Yasuhiro
• 金额: $ 12.98万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19380162/
• 关键词: マウス; 精巣; 卵巣; 始原生殖細胞; 精巣内卵細胞; 性決定因子; セルトリ細胞; 透明帯; 卵細胞; MRLマウス; 減数分裂; 原始卵胞; 受精; SYCP3; Sry; MRL; MpJ; CAGリピート; 自己免疫疾患; 減数分裂中期特異的アポトーシス; Exol

The oocytes exist in seminiferous tubules of male MRL mice. As a result of the analysis, the testicular oocytes had several similar developmental dynamics, morphological characteristics, and functions to the ovarian oocytes. In the male MRL, the summaries are the following ; 1) the meiosis has already begun during embryogenesis, 2) sry mutation, male sex-determining factor was related with appearance of testicular oocytes, and 3) testicular oocytes have an ability for sperm acceptance. These results suggest an important finding that develop a new reproductive biology by the concept having an exchangeable availability of primordial germ cells from male to female.

卵母细胞存在于雄性MRL小鼠的生精小管中。分析结果表明，睾丸卵母细胞具有与卵巢卵母细胞相似的发育动力学、形态特征和功能。在雄性MRL中，1)减数分裂已经开始，2)Sry突变，男性性别决定因素与睾丸卵母细胞的出现有关，3)睾丸卵母细胞具有接受精子的能力。这些结果表明了一个重要的发现，即通过具有可交换的原始生殖细胞从男性到女性的概念来开发一种新的生殖生物学。

项目成果

Strain differences of cerebral ventricles in mice. Can MRL/MpJ mouse be a model for hydrocephalus?

小鼠脑室应变差异。

• 发表时间: 2009
• 期刊: Jpn.J.Vet.Res.,. 57
• 作者: Hino;k.
• 通讯作者: k.

MRLマウスの精細胞アポトーシスに影響する第2染色体因子

影响MRL小鼠精子细胞凋亡的2号染色体因素

• 发表时间: 2008
• 作者: Astrid Ardiyanti;ら;昆泰寛
• 通讯作者: 昆泰寛

A new amphiphilic derivative, N{[4-(lactobionamido)methyl]benzylidene}- 1,1-dimethyl-2- (octylsulfanyl) ethylamine N-oxide, has a protective effect againgst copper-induced fulminant hepatitis in Long-Evans Cinnamon rats at an extremely low concentration c

一种新型两亲衍生物 N{[4-(乳生物酰胺基)甲基]亚苄基}- 1,1-二甲基-2-(辛基硫基)乙胺 N-氧化物，对 Long-Evans Cinnamon 大鼠铜诱导的暴发性肝炎具有保护作用

• 发表时间: 2007
• 期刊: Chem Biodivers 4(9)
• 作者: Khan;M. Z. I.;Asanuma T
• 通讯作者: Asanuma T

Onset of autoimmune glomerulonephritis derived from the telomeric region of MRL-chromosome 1 is associated with the male sex hormone in mice

• DOI: 10.1177/0961203308098989
• 发表时间: 2009-05-01
• 期刊: LUPUS
• 影响因子: 2.6
• 作者: Ichii, O.;Konno, A.;Kon, Y.
• 通讯作者: Kon, Y.

Quantitative trait loci analysis of development of ovarian cysts originated from rete ovarii in the MRL/MpJ mice

MRL/MpJ 小鼠卵巢网来源卵巢囊肿发育的数量性状位点分析

• 发表时间: 2009
• 作者: Lee;S. -H
• 通讯作者: S. -H