Development of reproductive biology by analysis of oocyte-producing male mouse strain

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The oocytes exist in seminiferous tubules of male MRL mice. As a result of the analysis, the testicular oocytes had several similar developmental dynamics, morphological characteristics, and functions to the ovarian oocytes. In the male MRL, the summaries are the following ; 1) the meiosis has already begun during embryogenesis, 2) sry mutation, male sex-determining factor was related with appearance of testicular oocytes, and 3) testicular oocytes have an ability for sperm acceptance. These results suggest an important finding that develop a new reproductive biology by the concept having an exchangeable availability of primordial germ cells from male to female.