Regulation of mesenchymal stem cell differentiation by growth hormone

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Age-related decline in growth hormone (GH) secretion results in the loss of skeletal muscle (sarcopenia) and bone mass (osteopenia). The specific aim of the present research was to test, using human GH-transgenic rats whose GH secretion is severely suppressed, whether sarcopenia and osteopenia caused by lowered secretion/action of GH is related to the decrease in the differentiation potential of mesenchymal stem cells (MSC) in skeletal muscle and bone. The results obtained clearly indicated that GH plays a role in the maintenance of MSC function both in skeletal muscle and bone.