Possible pharmacokinetic drug-drug interaction during corticosteroid therapy in dogs
Possible pharmacokinetic drug-drug interaction during corticosteroid therapy in dogs
批准号:
19380176
负责人:
SHIMODA Minoru
金额:
$7.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
In this study we examined possible pharmacokinetic drug-drug interaction by corticosteroid treatment in dogs. As a result, predonisolone, triamucinolone and hydrocortisone affected oxidative metabolism and the levels of drug binding protein in plasma. These corticosteroids may, therefore, result in adverse effects of some drugs, which are co-medicated, through altering biotransformation rate and distribution of the co-medicated drugs.
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会议论文
ラットにおける消炎ステロイド投与の肝CYP酵素活性に対する影響
抗炎类固醇给药对大鼠肝CYP酶活性的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Yamanokuchi K, Yabuki A, Yoshimoto Y, Arai K, Fujiki M, Misumi K, 飯沼雄司]
通讯作者:
飯沼雄司
犬におけるステロイド系抗炎症薬の投与が肝CYP酵素活性に及ぼす影響について
甾体抗炎药对犬肝CYP酶活性的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shin JH, Sakoda Y, Yano S, Ochiai K, Kida H, Umemura T, 田中由衣]
通讯作者:
田中由衣
犬におけるステロイドのCYP活性に対する阻害作用
类固醇对犬CYP活性的抑制作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Yamanokuchi K, Yabuki A, Yoshimoto Y, Arai K, Fujiki M, Misumi, K, 島田圭吾]
通讯作者:
島田圭吾
Possible pharmacokinetic drug-drug interaction by some drugs inhibiting cytochrome P450 activities in dogs
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批准号:14560262
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:2002
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负责人:SHIMODA Minoru
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依托单位:
Effects of Acute Phase Response on Pharmacokinetics of Drugs in Dogs
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批准号:10839006
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:1998
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负责人:SHIMODA Minoru
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依托单位:
海外基金