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Possible pharmacokinetic drug-drug interaction during corticosteroid therapy in dogs

Possible pharmacokinetic drug-drug interaction during corticosteroid therapy in dogs
狗皮质类固醇治疗期间可能存在的药代动力学药物相互作用
批准号:
19380176
负责人:
SHIMODA Minoru
金额:
$7.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
In this study we examined possible pharmacokinetic drug-drug interaction by corticosteroid treatment in dogs. As a result, predonisolone, triamucinolone and hydrocortisone affected oxidative metabolism and the levels of drug binding protein in plasma. These corticosteroids may, therefore, result in adverse effects of some drugs, which are co-medicated, through altering biotransformation rate and distribution of the co-medicated drugs.
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DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Yamanokuchi K, Yabuki A, Yoshimoto Y, Arai K, Fujiki M, Misumi K, 飯沼雄司]
通讯作者: 飯沼雄司
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Shin JH, Sakoda Y, Yano S, Ochiai K, Kida H, Umemura T, 田中由衣]
通讯作者: 田中由衣
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Yamanokuchi K, Yabuki A, Yoshimoto Y, Arai K, Fujiki M, Misumi, K, 島田圭吾]
通讯作者: 島田圭吾
Possible pharmacokinetic drug-drug interaction by some drugs inhibiting cytochrome P450 activities in dogs
Effects of Acute Phase Response on Pharmacokinetics of Drugs in Dogs
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