Identification of molecular targets for human pancreatic cancer
Identification of molecular targets for human pancreatic cancer
批准号:
19390106
负责人:
FURUKAWA Toru
金额:
$11.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
To identify novel diagnostic and therapeutic molecular targets for pancreatic cancer, we carried out RNA interference-mediated systemic knockdown screening of downstream targets of MAPK, which led us to identify novel therapeutic molecular targets repressing survival, proliferation, and tumorigenesity of pancreatic cancer cells. We constructed a detection system in serum for overexpressed molecules in pancreatic cancer and found a candidate serum diagnostic marker that was elevated in patients' serum. Short RNA intereference sequences specific for the therapeutic target molecules were filed for a patent application.
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Oncocytic feature
嗜酸细胞特征
DOI:
--
发表时间:
期刊:
病理と臨床 (印刷中)
影响因子:
--
作者:
[Kaneko I, Hishinuma T, Suzuki K, Owada Y, Kitanaka N, Kondo H, Goto J, Furukawa H, Ono M., 古川徹]
通讯作者:
古川徹
Agaricus blazei Murrill hot water extract inhibits growth of and induces apoptosis in human pancreatic cell cells.
姬松茸热水提取物抑制人胰腺细胞的生长并诱导其凋亡。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Matsushita Y, Furukawa T, et al.]
通讯作者:
et al.
DOI:
10.1097/pas.0b013e3181a162e5
发表时间:
2009-08-01
期刊:
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
影响因子:
5.6
作者:
[Yamaguchi, Hiroshi, Shimizu, Michio, Furukawa, Toru]
通讯作者:
Furukawa, Toru
IPMNの病理
IPMN病理
DOI:
--
发表时间:
2014
期刊:
臨床消化器内科
影响因子:
--
作者:
[Furukawa T., 古川徹]
通讯作者:
古川徹
Future aspects of medical sciences and education "Challenge of integrated medical sciences"(Nadal-Ginard B, Takakura K (eds), Targeting targets of MAPK to treat cancer)
医学科学和教育的未来方面“综合医学科学的挑战”(Nadal-Ginard B,Takakura K(编辑),以 MAPK 治疗癌症为目标)
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[R. Moloud, M. Ono, Furukawa T]
通讯作者:
Furukawa T
共 36 条
Identification of susceptible genes in familial pancreatic cancer in Japan
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批准号:24390090
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.23万
-
财政年份:2012
-
负责人:FURUKAWA Toru
-
依托单位:
Identification of molecular targets associated with activation of GPCR signal pathway in pancreatic cancer
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批准号:24659167
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
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财政年份:2012
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负责人:FURUKAWA Toru
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依托单位:
Curing of pancreatic cancer by DUSPG/MKP-3
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批准号:15590295
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
-
财政年份:2003
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负责人:FURUKAWA Toru
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依托单位:
Experimental gene therapy employing DUSP6/MKP-3 for pancreatic cancer
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批准号:13670161
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2001
-
负责人:FURUKAWA Toru
-
依托单位:
Identification of tumor suppressor genes by means of a genomic clone-transfer
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批准号:11671147
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:1999
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负责人:FURUKAWA Toru
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依托单位:
Establishment of efficient treatment strategies for the pancreatic cancer based on its molecular characteristics
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批准号:10557116
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.51万
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财政年份:1998
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负责人:FURUKAWA Toru
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依托单位:
Study on Human Cytomegalovirus Proteins - specifically on 65 kDa protein -
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批准号:63570214
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
-
财政年份:1988
-
负责人:FURUKAWA Toru
-
依托单位:
Influence of Fracture Bhehvoir on the Rotating Bending Fatigue Properties of Sureface Hardened Steel
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批准号:60460201
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$5.57万
-
财政年份:1985
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负责人:FURUKAWA Toru
-
依托单位:
海外基金