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Identification of molecular targets for human pancreatic cancer

Identification of molecular targets for human pancreatic cancer
人类胰腺癌分子靶标的鉴定
批准号:
19390106
负责人:
FURUKAWA Toru
金额:
$11.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
To identify novel diagnostic and therapeutic molecular targets for pancreatic cancer, we carried out RNA interference-mediated systemic knockdown screening of downstream targets of MAPK, which led us to identify novel therapeutic molecular targets repressing survival, proliferation, and tumorigenesity of pancreatic cancer cells. We constructed a detection system in serum for overexpressed molecules in pancreatic cancer and found a candidate serum diagnostic marker that was elevated in patients' serum. Short RNA intereference sequences specific for the therapeutic target molecules were filed for a patent application.
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会议论文
Oncocytic feature
嗜酸细胞特征
DOI: --
发表时间:
期刊: 病理と臨床 (印刷中)
影响因子: --
作者: [Kaneko I, Hishinuma T, Suzuki K, Owada Y, Kitanaka N, Kondo H, Goto J, Furukawa H, Ono M., 古川徹]
通讯作者: 古川徹
Agaricus blazei Murrill hot water extract inhibits growth of and induces apoptosis in human pancreatic cell cells.
姬松茸热水提取物抑制人胰腺细胞的生长并诱导其凋亡。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Matsushita Y, Furukawa T, et al.]
通讯作者: et al.
DOI: 10.1097/pas.0b013e3181a162e5
发表时间: 2009-08-01
期刊: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
影响因子: 5.6
作者: [Yamaguchi, Hiroshi, Shimizu, Michio, Furukawa, Toru]
通讯作者: Furukawa, Toru
IPMNの病理
IPMN病理
DOI: --
发表时间: 2014
期刊: 臨床消化器内科
影响因子: --
作者: [Furukawa T., 古川徹]
通讯作者: 古川徹
36
    Identification of susceptible genes in familial pancreatic cancer in Japan
    • 批准号:
      24390090
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.23万
    • 财政年份:
      2012
    • 负责人:
      FURUKAWA Toru
    • 依托单位:
    Identification of molecular targets associated with activation of GPCR signal pathway in pancreatic cancer
    • 批准号:
      24659167
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.58万
    • 财政年份:
      2012
    • 负责人:
      FURUKAWA Toru
    • 依托单位:
    Curing of pancreatic cancer by DUSPG/MKP-3
    • 批准号:
      15590295
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2003
    • 负责人:
      FURUKAWA Toru
    • 依托单位:
    Experimental gene therapy employing DUSP6/MKP-3 for pancreatic cancer
    • 批准号:
      13670161
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2001
    • 负责人:
      FURUKAWA Toru
    • 依托单位:
    海外基金