Study of mechanism and treatment of chronic musculoskeletal pain.

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In this study, we investigate the mechanisms and subjective indicators of chronic pain. We also evaluated the treatment of chronic pain patients by a multidisciplinary treatment program. An elctrophysiological study using the patch-clump method revealed increased Na^<2+> current and excitability of the DRG neuron in the root constriction model. The sympathetic nervous system also appeared to contribute to chronic radicular pain. In addition, activation of the glial cells and excitation of the substantia gelatinosa neuron may also contribute to chronic pain in the dorsal horn of spinal cord. Serum concentrations of CGRP and galanin were found to correlate to pain intensity in patients with lumbar disc herniation. Scores for SF-36 and self-efficacy were found to be lower in chronic low-back pain patients, and the multidisciplinary treatment program was effective in improving SF-36 scores in patients with chronic pain.