Analysis of correlation of angiogeneis and osteoclastogenesis/osteoclastic bone resorption in tumore-induced destruction of bone
Analysis of correlation of angiogeneis and osteoclastogenesis/osteoclastic bone resorption in tumore-induced destruction of bone
批准号:
19390397
负责人:
IWAMOTO Yukihide
金额:
$11.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010
中文摘要
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英文摘要
The molecular mechanism of tumor-induced bone destruction was investigated in this study. In tumor-induced bone destruction, tumora-associated macropahges (TAM) play major roles as a cell factor. As soluble factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are found to be critical in the tumor-induced bone destruction. Together, TAM, VEGF, and bFGF would be promising molecular targets for treating the tumor-induced bone destruction.
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DOI:
10.1111/j.1365-2559.2008.03050.x
发表时间:
2008-06-01
期刊:
HISTOPATHOLOGY
影响因子:
6.4
作者:
[Kaibara, N., Yamada, H., Iwamoto, Y.]
通讯作者:
Iwamoto, Y.
Recently established concepts in soft tissue tumors
最近建立的软组织肿瘤概念
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[岡本竜哉, 他, Oda Y]
通讯作者:
Oda Y
Multiinstitutional phase II study of neoadjuvant chemotherapy for osteosarcoma(NECC study)in Japan : NECO-93J and NECO-95J.
日本骨肉瘤新辅助化疗多机构II期研究(NECC研究):NECO-93J和NECO-95J。
DOI:
--
发表时间:
2009
期刊:
J Orthop Sci, 14(4) :
影响因子:
--
作者:
[Iwamoto Y, et al.:]
通讯作者:
et al.:
Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors.
散发性硬纤维瘤中 β-连环蛋白广泛核表达与基质金属蛋白酶 7 过表达之间的相关性。
DOI:
--
发表时间:
2008
期刊:
Hum Pathol 39(12)
影响因子:
--
作者:
[Matono H, Iwamoto Y, et al.]
通讯作者:
et al.
A novel tumor necrosis factor-α responsive CCAAT/Enhancer -binding protein site regulates cartilage Cd-Rap expression.
一种新的肿瘤坏死因子-α 响应性 CCAAT/增强子结合蛋白位点调节软骨 Cd-Rap 表达。
DOI:
--
发表时间:
2008
期刊:
Arthritis Rheum 58(5)
影响因子:
--
作者:
[Imamura T, Iwamoto Y, et al.]
通讯作者:
et al.
共 96 条
Analysis on oncogenic mechanisms and therapeutic targets in Ewing's sarcoma
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批准号:14207057
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$32.86万
-
财政年份:2002
-
负责人:IWAMOTO Yukihide
-
依托单位:
Molecular targets for signal transduction involved in the invasion and metastasis of malignant bone and soft tissue tumors.
-
批准号:12557125
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.19万
-
财政年份:2000
-
负责人:IWAMOTO Yukihide
-
依托单位:
EWS-Fli1 fusion gene as a diagnostic and therapeutic molecule for Ewing's sarcoma and PNET
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批准号:10307034
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项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$25.08万
-
财政年份:1998
-
负责人:IWAMOTO Yukihide
-
依托单位:
The study of the expression of MMPs and TIMPs in malignant bone and soft tissue tumors, its regulation and therapeutic application
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批准号:09557124
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.04万
-
财政年份:1997
-
负责人:IWAMOTO Yukihide
-
依托单位:
MECHANISMS AND INHITION OF THE INVASION OF MALIGNANT BONE AND SOFT TISSUE TUMORS THROUGH BASEMENT MEMBRANES
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批准号:06671462
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.15万
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财政年份:1994
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负责人:IWAMOTO Yukihide
-
依托单位:
USE OF RECONSTITUTED BASEMENT MEMBRANE EXTRACTS TO STUDY OF THE MECHANISMS OF THE INVASION OF MALIGNANT TUMORS THROUGH BASEMENT MEMBRANES
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批准号:02807140
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.15万
-
财政年份:1990
-
负责人:IWAMOTO Yukihide
-
依托单位:
海外基金