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Analysis of correlation of angiogeneis and osteoclastogenesis/osteoclastic bone resorption in tumore-induced destruction of bone

Analysis of correlation of angiogeneis and osteoclastogenesis/osteoclastic bone resorption in tumore-induced destruction of bone
肿瘤引起的骨破坏中血管生成与破骨细胞生成/破骨细胞骨吸收的相关性分析
批准号:
19390397
负责人:
IWAMOTO Yukihide
金额:
$11.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010

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中文摘要
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英文摘要
The molecular mechanism of tumor-induced bone destruction was investigated in this study. In tumor-induced bone destruction, tumora-associated macropahges (TAM) play major roles as a cell factor. As soluble factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are found to be critical in the tumor-induced bone destruction. Together, TAM, VEGF, and bFGF would be promising molecular targets for treating the tumor-induced bone destruction.
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DOI: 10.1111/j.1365-2559.2008.03050.x
发表时间: 2008-06-01
期刊: HISTOPATHOLOGY
影响因子: 6.4
作者: [Kaibara, N., Yamada, H., Iwamoto, Y.]
通讯作者: Iwamoto, Y.
Recently established concepts in soft tissue tumors
最近建立的软组织肿瘤概念
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [岡本竜哉, 他, Oda Y]
通讯作者: Oda Y
Multiinstitutional phase II study of neoadjuvant chemotherapy for osteosarcoma(NECC study)in Japan : NECO-93J and NECO-95J.
日本骨肉瘤新辅助化疗多机构II期研究(NECC研究):NECO-93J和NECO-95J。
DOI: --
发表时间: 2009
期刊: J Orthop Sci, 14(4) :
影响因子: --
作者: [Iwamoto Y, et al.:]
通讯作者: et al.:
Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors.
散发性硬纤维瘤中 β-连环蛋白广泛核表达与基质金属蛋白酶 7 过表达之间的相关性。
DOI: --
发表时间: 2008
期刊: Hum Pathol 39(12)
影响因子: --
作者: [Matono H, Iwamoto Y, et al.]
通讯作者: et al.
96
    Analysis on oncogenic mechanisms and therapeutic targets in Ewing's sarcoma
    • 批准号:
      14207057
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $32.86万
    • 财政年份:
      2002
    • 负责人:
      IWAMOTO Yukihide
    • 依托单位:
    Molecular targets for signal transduction involved in the invasion and metastasis of malignant bone and soft tissue tumors.
    • 批准号:
      12557125
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.19万
    • 财政年份:
      2000
    • 负责人:
      IWAMOTO Yukihide
    • 依托单位:
    EWS-Fli1 fusion gene as a diagnostic and therapeutic molecule for Ewing's sarcoma and PNET
    • 批准号:
      10307034
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $25.08万
    • 财政年份:
      1998
    • 负责人:
      IWAMOTO Yukihide
    • 依托单位:
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    • 批准号:
      09557124
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $7.04万
    • 财政年份:
      1997
    • 负责人:
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    • 依托单位:
    海外基金