Induction of kidney graft tplerance using donor-specofoc regulatory T cells

使用供体特异性调节 T 细胞诱导肾移植不耐受

• 批准号: 19390414
• 负责人: TAKAHARA Shiro
• 金额: $ 11.98万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390414/
• 关键词: 腎移植; 免疫寛容; 腎臓移植; 制御性T細胞; superagonistCD28抗体; Foxp3

Regulatory T (Treg) cells play an important role in graft tolerance. We examined whether a superagonistic monoclonal antibody specific for CD28 (CD28SA), using rat acute renal allograft model (Wistar to Lewis). CD28SA induced marked infiltration of Treg cells into the allografts. 90% of recipients treated with CD28SA survived over 100 days, and 70% survived with well-preserved graft function until graft harvest at 180 days. Furthermore, these long-surviving recipients showed donor-specific tolerance. In conclusion, CD28SA treatment successfully induces donor-specific tolerance with the involvement of Treg cells, and thus the therapeutic value of this approach warrants further investigation and preclinical studies.

调节性T（Treg）细胞在移植耐受中起重要作用。我们用大鼠急性肾移植模型（Wistar to刘易斯）检测了是否存在特异性CD28的超激动性单克隆抗体（CD28 SA）。CD28SA诱导Treg细胞显著浸润同种异体移植物。接受CD28SA治疗的受者中有90%存活超过100天，70%的受者在180天移植物收获前存活并保持良好的移植物功能。此外，这些长期存活的受体表现出供体特异性耐受。总之，CD28SA治疗成功诱导了Treg细胞参与的供体特异性耐受，因此这种方法的治疗价值值得进一步研究和临床前研究。

项目成果

Superagonistic CD28 antibody induces donor-specific tolerance in rat renal allografts

• DOI: 10.1111/j.1600-6143.2008.02358.x
• 发表时间: 2008-10-01
• 期刊: AMERICAN JOURNAL OF TRANSPLANTATION
• 影响因子: 8.8
• 作者: Azuma, H.;Isaka, Y.;Takahara, S.
• 通讯作者: Takahara, S.

A Superagonistic Monoclonal Antibody for CD28 Induced Donor-Specific Tolerance.

针对 CD28 诱导的供体特异性耐受的超激动单克隆抗体。

• 发表时间: 2007
• 作者: Nakamura K;Kogure K;Kubota K;Ikeda S;Minegishi T;Isaka Y
• 通讯作者: Isaka Y

Systemic administration of siRNA targeting p53 protects kidneys from ischemia-reperfusion injury in experimental rat kidney transplantation model.

在实验性大鼠肾移植模型中，全身施用靶向 p53 的 siRNA 可保护肾脏免受缺血再灌注损伤。

• 发表时间: 2008
• 作者: Mabuchi;S.;Ugaki;H.;Isohashi;F.;Yoshioka;Y.;Temma;K.;Yoda-Hashimoto;N.;Takeda;T.;Yamamoto;T.;Yoshino;K.;Nakajima;R.;Kuragaki;C.;Morishige;K.;Enomoto;T.;Inoue;T.;Kimura;T.;石橋宰;Isaka Y
• 通讯作者: Isaka Y

Nonerythropoietic derivative of erythropoietin protects against tubulointerstitial injury in a unilateral ureteral obstruction model

• DOI: 10.1093/ndt/gfm842
• 发表时间: 2008-05-01
• 期刊: NEPHROLOGY DIALYSIS TRANSPLANTATION
• 影响因子: 6.1
• 作者: Kitamura, Harumi;Isaka, Yoshitaka;Imai, Enyu
• 通讯作者: Imai, Enyu

Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production

• DOI: 10.1016/j.intimp.2009.01.025
• 发表时间: 2009-05-01
• 期刊: INTERNATIONAL IMMUNOPHARMACOLOGY
• 影响因子: 5.6
• 作者: Xie, Lin;Li, Xiao-Kang;Takahara, Shiro
• 通讯作者: Takahara, Shiro