Self-organization mechanisms of topology of local neural circuit

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In this study, we investigated the dynamics and self-organization of cortical local neural network by electrophysiological experiments on acute brain slices, mathematical modeling and computer simulations of realistic neural network. It was found that autonomous change of functional neural connections occurred associated with metastable dynamics of ensemble neuronal activities in the local neural circuit. In addition, it is suggested that a certain degree of robustness of the distribution of efficacy of functional neuronal connections against the self-organization of the network.