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Noninvasive evaluation of the carotid plaque characteristics based on regional strain measurement using two-dimensional speckle tracking imaging

基于二维散斑跟踪成像的区域应变测量的颈动脉斑块特征的无创评估

基本信息

批准号：
19500412
负责人：
MIKAMI Taisei
金额：
$ 2.91万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2007
资助国家：
日本
起止时间：
2007 至 2009
项目状态：
已结题

项目摘要

There has been no established method to measure distensibility of a specific area of medium-sized artery wall. We attempted to measure segmental strain of the carotid artery wall using ultrasonic 2-dimensional speckle tracking method and investigate the relationship to the local atherosclerotic lesions. Two-hundred carotid arteries of 100 patients with ischemic cerebrovascular disease were studied and the far wall of the common carotid artery in long-axis B-mode image was divided into 5 segments. In each segment, the longitudinal and radial peak strain and intima-media thickness (IMT) were measured. Strain measurements were possible in 885 of the 1000 segments (88.5%), and the radial peak strain was significantly reduced in the segments with plaque (IMT>=1.2mm, -3.53+/-2.79%) than those without (-4.67+/-2.85%, p<0.0001). Two-dimensional speckle tracking imaging may be useful to measure regional distensibility of the carotid atherosclerotic lesions.

目前还没有确定的方法来测量中等大小动脉壁特定区域的扩张性。我们尝试采用超声二维散斑追踪法测量颈动脉壁的节段应变，并探讨其与局部动脉粥样硬化病变的关系。对100例缺血性脑血管病患者的200条颈动脉进行研究，将长轴B型图像中颈总动脉的远壁分为5段。在每个节段中，测量纵向和径向峰值应变以及内膜中层厚度（IMT）。 1000 个节段中的 885 个节段 (88.5%) 可以进行应变测量，并且有斑块的节段 (IMT>=1.2mm, -3.53+/-2.79%) 的径向峰值应变显着低于没有斑块的节段 (-4.67+/-2.85%, p<0.0001)。二维斑点跟踪成像可用于测量颈动脉粥样硬化病变的区域扩张性。