Decrease in advanced glycation end-product (AGE) by short-term lifestyle modification in non-diabetic obese subjects

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Advanced glycation end products (AGEs) play an important role in development of atherosclerosis. There is currently little information available on the effects of lifestyle modification (LM) on circulating AGEs in obese subjects. Serum levels of Ne-(carboxymethyl) lysine (CML), pentosidine, derivatives of reactive oxygen metabolites (d-ROMs), and adipokines were determined in obese population. The present findings shows that number of steps in daily walking and decreases in body fat mass were significantly correlated with decrease in serum CML level. The study suggests the possibilities that the LM could be a promising approach to prevent the development of atherosclerotic diseases by reducing the AGEs formation.