Construction of a system to develop immunotherapy by exploiting the computational algorithm to identify HLA-binding peptides.

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We have developed a system to establish immunotherapies against tumors and viruses by exploiting the computational algorithm to identify HLA-binding peptides. We further developed a method to recruit Th1 cells by including Pertussis whole cell vaccine as an adjuvant in order to induce highly cytotoxic T lymphocytes. After testing on mouse models we conducted phase I/II clinical trials for patients suffering from malignant tumors or chronic hepatitis C virus infection. Tumor control rate obtained was twice the percentage using HLA-binding peptides alone. A long-term tumor control was further observed.