Effects of exposure to endocrine disruptor during gestation and lactation period on motherhood in female mice.
Effects of exposure to endocrine disruptor during gestation and lactation period on motherhood in female mice.
批准号:
19530659
负责人:
TOMIHARA Kazuya
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010
中文摘要
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英文摘要
The aim of this study was to demonstrate effects of endocrine disruption during gestation and lactation period on motherhood. We orally administered diethylstilbestrol (DES), a synthetic nonsteroidal estrogen, to pregnant female mice of C57BL/6j strain from their gestation day 11 to 17, or to postpartum day 6, and then investigated their maternal, emotional, social, and learning behavior. As the results, the endocrine disruption during gestation period influenced many behavioral aspects of mother, such as decreased maternal behavior and prevention of learning, although all of the effects may not give the mother a disadvantage.
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胎児期diethylstilbestrol (DES)曝露が雌雄マウスのopen field行動に及ぼす影響
胎儿己烯雌酚 (DES) 暴露对雄性和雌性小鼠旷场行为的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Tomihara, K., et al., 富原一哉・新保めぐみ, 井ノ上聡・富原一哉]
通讯作者:
井ノ上聡・富原一哉
妊娠期 diethylstilbestrol (DES) 投与がメスマウスの出産後の行動に及ぼす影響
孕期给予己烯雌酚(DES)对雌性小鼠产后行为的影响
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Tsuda M., et al. ., 富原一哉・松元沙, 富原一哉・松元沙, 富原一哉・田中歩, 金津将庸・山本洋紀・澤本伸克・福山秀直・齋木潤, 富原一哉・田中歩, 金津将庸, 富原一哉・中村加奈子, 富原一哉・中村加奈子]
通讯作者:
富原一哉・中村加奈子
Effect of ER-β gene disruption on estrogenic regulation of anxiety in female mice.
ER-β基因破坏对雌性小鼠焦虑雌激素调节的影响。
DOI:
--
发表时间:
2009
期刊:
Physiology & Behavior 96
影响因子:
--
作者:
[Kazuya Tomihara, Tomoko Soga, Masayoshi Nomura, Kenneth S.Korach, Jan-Ake Gustafsson, Donald W.Pfaff, Sonoko Ogawa]
通讯作者:
Sonoko Ogawa
妊娠期の内分泌かく乱がメス親マウスの空間学習に及ぼす効果
妊娠期内分泌干扰对母鼠空间学习的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Tomihara, K., et al., 富原一哉・新保めぐみ, 井ノ上聡・富原一哉, 富原一哉・石橋佐和子]
通讯作者:
富原一哉・石橋佐和子
周産期 diethylstilbestrol 曝露がメス親マウスの社会行動に及ぼす効果
围产期己烯雌酚暴露对母鼠社会行为的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Tsuda M., et al. ., 富原一哉・松元沙, 富原一哉・松元沙, 富原一哉・田中歩, 金津将庸・山本洋紀・澤本伸克・福山秀直・齋木潤, 富原一哉・田中歩]
通讯作者:
富原一哉・田中歩
共 28 条
Fundamental research of the onset mechanism of emotional disorders in perinatal women.
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批准号:17K04493
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2017
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负责人:TOMIHARA Kazuya
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依托单位:
A study of neuroendocrinological mechanisms underlying a women's vulnerability to emotional disorders
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批准号:23530957
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:TOMIHARA Kazuya
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依托单位:
海外基金