Establishment of hierarchical structure analysis of proteins insolutions by high-throughput of wide-angle X-rays scattering usingsynchrotron radiation source

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The wide-angle X-ray scattering using the third generation synchrotron radiation source is a promising and powerful method elucidating in-situ hierarchical structures of proteins at those functional states. By the excution of this study aimed for the establishment of the solution X-ray wide-angle scattering, we can get scattering data with high statistics precision while avoiding radiation damage, and we clarified the relation between hydration shell and structural transition of a protein, the all processes of nucleation / growth in the amyloid metastasis, the change of dynamics of a protein induced by the amyloid transition (α-to-cross-β).We published the aobve results of this project in 11 full articles in academic journals and in 23 papers at overseas international conferences and at domestic academic society meetings.