Stimulatory effect of heparin-binding EGF-like growth factor on the proliferation of bovine endometrial cells

肝素结合EGF样生长因子对牛子宫内膜细胞增殖的刺激作用

• 批准号: 19580335
• 负责人: KIZAKI Keiichiro
• 金额: $ 2.91万
• 依托单位: Iwate University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19580335/
• 关键词: ヘパリン結合性EGF様増殖因子; MMP; 子宮; 胎盤; ヘパラナーゼ; マトリックスメタロプロテアーゼ; 妊娠; ヘパリン結合性EGF様増殖固子

Heparin-binding EGF-like growth factor (HBEGF) participates in a wide range of physiological and pathological processes through its receptor EGFR. The aim of this study was to identify the expression of HBEGF and EGFR in bovine endometrium, and investigate the role of this system during implantation and placentation in cattle. Present results demonstrate that HBEGF-EGFR signaling system presents in bovine endometrium, and exhibits proliferation potential to the endometrial cells, indicating that the system play crucial role in implantation and placental development in cattle.

肝素结合表皮生长因子样生长因子（HBEGF）通过其受体EGFR参与多种生理和病理过程。本研究的目的是鉴定牛子宫内膜中HBEGF和EGFR的表达，并探讨该系统在牛着床和胎盘形成过程中的作用。本研究结果表明，牛子宫内膜存在HBEGF-EGFR信号系统，该系统对子宫内膜细胞具有促增殖作用，提示该系统在牛胚胎着床和胎盘发育中起重要作用。

项目成果

Model of the Caruncular Cell Proliferation in Bovine and Gene Expression Profiling in the Model

牛肉圆细胞增殖模型及模型中的基因表达谱

• 发表时间: 2008
• 作者: Kizaki K;Sugawara K;Hasegawa Y;Hashizume K.
• 通讯作者: Hashizume K.

ウシ栄養膜由来細胞系、BT-1細胞の増殖と分化に及ぼすRA、PMAおよびFGFの影響

RA、PMA和FGF对牛滋养层细胞系BT-1细胞增殖和分化的影响

• 发表时间: 2007
• 作者: 田中議顕;木崎景一郎;橋爪一善
• 通讯作者: 橋爪一善

ウシ栄養膜由来細胞系、BT-1細胞の増殖と分化に及ぽすRA、PMAおよびFGFの影響

RA、PMA和FGF对牛滋养层细胞系BT-1细胞增殖和分化的影响

• 发表时间: 2007
• 作者: 田中議顕;木崎景一郎;橋爪一善
• 通讯作者: 橋爪一善

Expression of extracellular matrix metalloproteinase inducer during bovine pregnancy

牛妊娠期细胞外基质金属蛋白酶诱导剂的表达

• 发表时间: 2009
• 作者: Mishra BM;Kizaki K;Ushizawa K;Takahashi T;Hosoe M;Sato T;Ito A;Hashizume K.
• 通讯作者: Hashizume K.

Expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and its related extracellular matrix degrading enzymes in the endometrium during estrous cycle and early gestation in cattle

• DOI: 10.1186/1477-7827-8-60
• 发表时间: 2010-06-11
• 期刊: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
• 影响因子: 4.4
• 作者: Mishra, Birendra;Kizaki, Keiichiro;Hashizume, Kazuyoshi
• 通讯作者: Hashizume, Kazuyoshi