Primary approach for therapy of fibrosis by manipulating angiogenesis induced by biologically active autocoids

通过操纵生物活性自体蛋白诱导的血管生成治疗纤维化的主要方法

• 批准号: 19590072
• 负责人: HAYASHI Izumi
• 金额: $ 2.08万
• 依托单位: Nihon Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590072/
• 关键词: オータコイド; 線維化; 血管新生; 生理活性; カルシトニン遺伝子関連ペプチド; 創傷治癒; 細胞・組織; 薬理学; プロスタグランジン; 神経ペプチド; リポキシン

Fibrosis is an essential event for repair of damaged tissue in wound healing. However, delay of wound healing or dysfunction of organ by excessive fibrosis resulting deterioration of prognosis in the disease. In the present study, calcitonin gene-related peptide (CGRP) neurogenically released from primary afferent sensory neurons, could repair the impaired tissue via angiogenesis, suggesting a significant involvement of the autocoid in formation of granuloma and fibrogenesis.

纤维化是创面愈合过程中受损组织修复的重要过程。然而，过度纤维化导致的伤口愈合延迟或器官功能障碍导致疾病预后恶化。在本研究中，从初级传入感觉神经元释放的降钙素基因相关肽（CGRP）可以通过血管生成修复受损组织，提示自身样蛋白在肉芽肿形成和纤维形成中有重要参与。

项目成果

Role of prostagladin (PG) and peroxisome proliferator-activated gamma (PPAR・) in pulmonary fibrosis.

前列腺素（PG）和过氧化物酶体增殖物激活γ（PPAR·）在肺纤维化中的作用。

• 发表时间: 2009
• 期刊: Current Respiratory Med Rev 5
• 作者: Hayashi I;Endo H;Katagiri M;Kitasato H
• 通讯作者: Kitasato H

Effects of inhaled monoethanolamine on bronchoconstristion.

吸入单乙醇胺对支气管收缩的影响。

• 发表时间: 2009
• 期刊: J Appl Toxicol. 29
• 作者: Kamijo Y;Hayashi I;Ide A;Yoshimura K;Soma K;Majima M
• 通讯作者: Majima M

Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis

• DOI: 10.1111/j.1349-7006.2009.01322.x
• 发表时间: 2009-12-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Amano, Hideki;Ito, Yoshiya;Majima, Masataka
• 通讯作者: Majima, Masataka

Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ucer healing and angiogenesis.

降钙素基因相关肽在维持胃粘膜完整性以及增强溃疡愈合和血管生成中的作用。

• 发表时间: 2008
• 期刊: Gastroenterology 134
• 作者: Ohno T;Hattori Y;Komine R;Ae T;Mizuguchi S;Arai K;Saeki T;Suzuki T;Hosono K;Hayashi I;Oh-Hashi Y;Kurihara Y;Kurihara H;Amagase K;Okabe S;Saigenji K;Majima M
• 通讯作者: Majima M

Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth

• DOI: 10.1016/j.bbrc.2009.03.094
• 发表时间: 2009-05-15
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Ogawa, Yasuhumi;Suzuki, Tatsunori;Majima, Masataka
• 通讯作者: Majima, Masataka