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Primary approach for therapy of fibrosis by manipulating angiogenesis induced by biologically active autocoids

Primary approach for therapy of fibrosis by manipulating angiogenesis induced by biologically active autocoids
通过操纵生物活性自体蛋白诱导的血管生成治疗纤维化的主要方法
批准号:
19590072
负责人:
HAYASHI Izumi
金额:
$2.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
Fibrosis is an essential event for repair of damaged tissue in wound healing. However, delay of wound healing or dysfunction of organ by excessive fibrosis resulting deterioration of prognosis in the disease. In the present study, calcitonin gene-related peptide (CGRP) neurogenically released from primary afferent sensory neurons, could repair the impaired tissue via angiogenesis, suggesting a significant involvement of the autocoid in formation of granuloma and fibrogenesis.
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Role of prostagladin (PG) and peroxisome proliferator-activated gamma (PPAR・) in pulmonary fibrosis.
前列腺素(PG)和过氧化物酶体增殖物激活γ(PPAR·)在肺纤维化中的作用。
DOI: --
发表时间: 2009
期刊: Current Respiratory Med Rev 5
影响因子: --
作者: [Hayashi I, Endo H, Katagiri M, Kitasato H]
通讯作者: Kitasato H
Effects of inhaled monoethanolamine on bronchoconstristion.
吸入单乙醇胺对支气管收缩的影响。
DOI: --
发表时间: 2009
期刊: J Appl Toxicol. 29
影响因子: --
作者: [Kamijo Y, Hayashi I, Ide A, Yoshimura K, Soma K, Majima M]
通讯作者: Majima M
DOI: 10.1111/j.1349-7006.2009.01322.x
发表时间: 2009-12-01
期刊: CANCER SCIENCE
影响因子: 5.7
作者: [Amano, Hideki, Ito, Yoshiya, Majima, Masataka]
通讯作者: Majima, Masataka
Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ucer healing and angiogenesis.
降钙素基因相关肽在维持胃粘膜完整性以及增强溃疡愈合和血管生成中的作用。
DOI: --
发表时间: 2008
期刊: Gastroenterology 134
影响因子: --
作者: [Ohno T, Hattori Y, Komine R, Ae T, Mizuguchi S, Arai K, Saeki T, Suzuki T, Hosono K, Hayashi I, Oh-Hashi Y, Kurihara Y, Kurihara H, Amagase K, Okabe S, Saigenji K, Majima M]
通讯作者: Majima M
15
    Cell therapy by manipulation of biological function of prostaglandin as self-defense factor
    Biological characterization of bradykinin receptor involved in functional control of airway
    • 批准号:
      12670094
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.15万
    • 财政年份:
      2000
    • 负责人:
      HAYASHI Izumi
    • 依托单位:
    海外基金