Protective mechanisms of water-soluble extract from culture medium of Ganoderma lucidum mycelia against neuronal damage after cerebral ischemia/reperfusion in diabetic state

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Diabetic Mellitus (DM) have been shown to enhance oxidative stress leading to aggravation of cerebral ischemic injury following stroke. In this study, we examined the effects of oral administration of a water-soluble extract from culture medium of Ganoderma lucidum mycelia (MAK) on blood glucose level (BG), total plasma oxidative stress, and activity of antioxidant enzymes in DM animals. Furthermore, neuroprotective effects of MAK against exacerbation of neuronal damage induced by cerebral ischemia/reperfusion in the DM animals were investigated. DM animals had increased BG and decreased activity of antioxidant enzymes in the brain. DM animals treated with MAK had significantly lower BG and normal activity of the antioxidant enzyme. Treatment of MAK remarkably improved aggravated neurological deficits and cerebral injury induced by ischemia/reperfusion in diabetic animals. These results show that daily intake of MAK relieves the exacerbation of cerebral ischemic injury in a diabetic state, which may be attributed to improvement of augmented oxidative stress.