HDL generation as an effector against inflammation and atherosclerosis

HDL 生成作为对抗炎症和动脉粥样硬化的效应物

• 批准号: 19591063
• 负责人: ABE-DOHMAE Sumiko
• 金额: $ 3万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591063/
• 关键词: HDL; ABCA1; ABCA7; SAA

各種培養細胞および遺伝子改変マウスを用い、α1アドレナリンレセプター阻害薬doxazosinのHDL上昇作用ならびに急性期反応における血中SerumamyloidAの濃度上昇が、いずれもABCA1を介したアポリポタンパク質依存性HDL新生反応の結果であることを示し、各々のメカニズムを明らかにした

A variety of cultured cell lines were modified to increase the concentration of SerumamyloidA in the acute phase.

项目成果

ATP-binding cassette transporter Al gene transcription is downregulated by activator protein 2alpha. Doxazosin inhibits activator protein 2alpha and increases high-density lipoprotein biogenesis independent of alphal-adrenoceptor blockade.

ATP结合盒转运蛋白A1基因转录被激活蛋白2α下调。

• 发表时间: 2007
• 期刊: Circ Res. 101
• 作者: Iwamoto N;Abe-Dohmae S;Ayaori M;Tanaka N;Kusuhara M;Ohsuzu F;and Yokovama S;Iwamoto N
• 通讯作者: Iwamoto N

Involvement of protein kinase D in phosphorylation and increase of DNA binding of activator protein 2 alpha to downregulate ATP-binding cassette transporter A1

蛋白激酶 D 参与磷酸化并增加激活蛋白 2 α 的 DNA 结合，从而下调 ATP 结合盒转运蛋白 A1

• 发表时间: 2008
• 期刊: Arterioscler Thromb Vase Biol 28
• 作者: Hu W;Abe-Dohmae S;Tsujita M;Iwamoto N;Ogikubo 0;Otsuka T;Kumon Y;and Yokoyama S;Iwamoto N
• 通讯作者: Iwamoto N

The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines

• DOI: 10.1016/j.bcp.2008.08.005
• 发表时间: 2008-10-15
• 期刊: BIOCHEMICAL PHARMACOLOGY
• 影响因子: 5.8
• 作者: Nishimaki-Mogami, Tomoko;Tamehiro, Norimasa;Sawada, Jun-ichi
• 通讯作者: Sawada, Jun-ichi

Involvement of protein kinase D in phosphorylation and increase of DNA binding of activator protein 2[alpha] to downregulate ATP-binding cassette transporter Al

蛋白激酶D参与磷酸化并增加激活蛋白2α的DNA结合以下调ATP结合盒转运蛋白A1

• 发表时间: 2008
• 期刊: Arterioscler Thromb Vasc Biol 28
• 作者: Iwamoto N;Abe-Dohmae S;Rui L;and Yokoyama S
• 通讯作者: and Yokoyama S

ATP-binding cassette transporter Al gene transcription is downregulated by activator protein 2alpha. Doxazosin inhibits activator protein 2alpha and increases high-density lipoprotein biogenesis independent of alphal-adrenoceptor blockade

ATP结合盒转运蛋白A1基因转录被激活蛋白2α下调。

• 发表时间: 2007
• 期刊: Circ Res 101
• 作者: Iwamoto N;Abe-Dohmae S;Ayaori M;Tanaka N;Kusuhara M;Ohsuzu F;and Yokovama S
• 通讯作者: and Yokovama S