Study of expression and physiological function of ARTEMIN, a family of glial cell line derived neurotrophic factor family, in skin

胶质细胞源性神经营养因子家族ARTEMIN在皮肤中的表达及生理功能研究

• 批准号: 19591304
• 负责人: MUROTA Hiroyuki
• 金额: $ 2.91万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591304/
• 关键词: 皮膚生理学

We focused on de novo synthesis of artemin (ARTN), which is a member of the glial cell line-derived neurotrophic factor related family, gene transcription in dermal fibroblast after substance P (SP)-stimulation. ARTN was accumulated in dermis of AD skin lesions, while not in that of psoriasis and healthy controls. SP-treated dermal fibroblast-derived artemin can be assumed to contribute to peripheral nerve sprouting. Furthermore, we found that ARTN contributed to development of SP-induced thermal hyperalgesia and compound 48/80-induced itch. From these results, we placed more expectations on ARTN for therapeutic target of intractable itch.

本论文主要研究了胶质细胞源性神经营养因子（glial cell line-derived neurotrophic factor，ARTN）家族成员artemin在P物质（substance P，SP）刺激下真皮成纤维细胞基因转录的从头合成。ARTN在AD皮损真皮中有明显蓄积，而在银屑病皮损和健康对照组中无明显蓄积。SP处理的真皮成纤维细胞衍生的artemin可以被认为有助于周围神经发芽。此外，我们发现ARTN有助于SP诱导的热痛觉过敏和化合物48/80诱导的瘙痒的发展。由此，我们对ARTN作为难治性瘙痒的治疗靶点寄予了更大的期望。

项目成果

痒みの新しいメカニズム : 皮膚アレルギー炎症における温度痛覚過敏の関与

瘙痒的新机制：温度痛觉过敏参与皮肤过敏性炎症

• 发表时间: 2008
• 作者: BAE Sangjae;et. al.;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;Hiroyuki Murota;室田浩之
• 通讯作者: 室田浩之

Artemin; the member of glial cell line-derived neutrophic factor is induced by substance P stimulated-fibroblasts and contributes peripheral nerve hyperplasia in the dermis of atopic dermatitis

阿尔特明；

• 发表时间: 2007
• 作者: BAE Sangjae;et. al.;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;Hiroyuki Murota;室田浩之;室田浩之;Murota Hiroyuki;Hiroyuki Murota
• 通讯作者: Hiroyuki Murota

【痒みをめぐる最近の話題】痒みはからだが暖まるとどうして増強するのですか

【最近关于瘙痒的话题】为什么身体变暖后瘙痒会加剧？

• 发表时间: 2009
• 期刊: Q&Aでわかるアレルギー疾患 5
• 作者: BAE Sangjae;et. al.;室田浩之;室田浩之;室田浩之;室田浩之
• 通讯作者: 室田浩之

Dermal fibroblasts in atopic dermatitis skin lesion synthesize ARTEMIN reactive with peripheral nerve.

特应性皮炎皮损中的真皮成纤维细胞合成与周围神经发生反应的ARTEMIN。

• 发表时间: 2008
• 作者: BAE Sangjae;et. al.;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;Hiroyuki Murota;室田浩之;室田浩之;Murota Hiroyuki
• 通讯作者: Murota Hiroyuki

温まると痒いのはなぜ

为什么一热就痒？

• 发表时间: 2009
• 作者: BAE Sangjae;et. al.;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之;室田浩之
• 通讯作者: 室田浩之