Study of expression and physiological function of ARTEMIN, a family of glial cell line derived neurotrophic factor family, in skin

我们重点研究了神经胶质细胞系来源的神经营养因子相关家族成员阿耳特素（ARTN）的新生合成，以及P物质（SP）刺激后真皮成纤维细胞的基因转录。ARTN在AD皮损真皮中有积累，而在牛皮癣和健康对照中没有。sp处理的真皮成纤维细胞衍生的青蒿素可以被认为有助于周围神经发芽。此外，我们发现ARTN有助于sp诱导的热痛觉过敏和复合48/80诱导的瘙痒的发展。从这些结果，我们对ARTN作为顽固性瘙痒的治疗靶点寄予了更多的期望。

We focused on de novo synthesis of artemin (ARTN), which is a member of the glial cell line-derived neurotrophic factor related family, gene transcription in dermal fibroblast after substance P (SP)-stimulation. ARTN was accumulated in dermis of AD skin lesions, while not in that of psoriasis and healthy controls. SP-treated dermal fibroblast-derived artemin can be assumed to contribute to peripheral nerve sprouting. Furthermore, we found that ARTN contributed to development of SP-induced thermal hyperalgesia and compound 48/80-induced itch. From these results, we placed more expectations on ARTN for therapeutic target of intractable itch.