Elucidation of brain morphological change and functional change at risk mental state

我们的研究显示，在精神分裂症患者中，各种白质区域的FA较低，这意味着白质完整性的破坏。在患者组中，胼胝体前部FA值与阴性症状严重程度呈负相关。在使用基于体素的弥散张量成像的研究中，与首发精神分裂症患者相比，ARMS有轻微的脑结构改变。这一发现归因于这样一个事实，即ARMS包括有精神病前驱症状的人，他们后来发展为精神病，而没有。我们用手工追踪方法进行的纵向研究表明，精神分裂症患者在发病早期表现出与明显精神病相关的进行性灰质减少。

Our investigation revealed lower FA in various white matter regions that implies the disruption of white matter integrity in schizophrenia patients. In the patient group, the FA value of the anterior part of the corpus callosum was negatively correlated with the severity of negative symptoms. In the study using the voxel-based diffusion tensor imaging, ARMS had mild structural brain change compared to first episode schizophrenia patients. This finding was ascribed to the fact that ARMS included people with prodromal signs of psychosis who developed psychosis later and had not. Our longitudinal study with manual tracing method, schizophrenia patients exhibit progressive gray matter reductions associated with overt psychosis in the early years of the illness.