Evaluation of the usefulness of NaF-PET in diagnosis of bone metastases from thyroid cancer in comparing with that of conventional Tc-99m-diphosphonate bone scintigraphy

分化型甲状腺癌(DTC)的骨转移在骨X线片上有时很难显示。常规~(99)m-二磷酸盐骨显像(CBS)用于检测DTC的骨转移。18F-NaF已在PET中用作寻骨剂。我们比较了NaF-PET和CBS在诊断DTC骨转移中的有效性。F-18NaF-PET和CBS的诊断能力是基于以下标准进行的：区分病变和正常骨结构的能力；视觉分辨率；以及区分感兴趣区的摄取、转移和骨关节炎的能力。骨显像在所有受试者中的总体准确度较高。CBS在区分病变和正常骨方面是准确的。但在其他两个标准中表现不佳。在骨性关节炎的PET研究中，对正常骨与转移骨的比率的定量评估有显著不同，而在CBS研究中则不同。

Bone metastases from differentiated thyroid carcinoma (DTC) are sometimes difficult to visualize on bone X-ray films. Conventional Tc-99m-diphosphonates bone scintigraphy (CBS) IS used for detecting bone metastases of DTC. 18F-NaF has been used in PET as a bone seeking agent. We evaluated the effectiveness of NaF-PET in comparison with CBS for the diagnosis of bone metastases in DTC. Diagnostic abilities of F-18 NaF-PET and CBS were examined visually based on the following criteria : ability to distinguish lesions from normal bone structure ; visual resolution ; and ability to distinguish uptake metastases and osteoarthritis in the ROIs. The overall accuracy of bone PET was higher in all subjects. CBS was accurate in distinguishing lesions from normal bone. but did not perform well in the other two criteria. Quantitative evaluation of the ratio of normal to metastatic bone was significantly different in PET studies but not in CBS studies of osteoarthritis.