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Evaluation of the usefulness of NaF-PET in diagnosis of bone metastases from thyroid cancer in comparing with that of conventional Tc-99m-diphosphonate bone scintigraphy

与传统 Tc-99m-二膦酸盐骨显像相比，评估 NaF-PET 在诊断甲状腺癌骨转移中的有效性

基本信息

批准号：
19591430
负责人：
KAWABE Joji
金额：
$ 2.33万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2007
资助国家：
日本
起止时间：
2007 至 2009
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591430/
关键词：
F-18フッ化ナトリウム骨ポジトロンCT 骨PET Tc-99m-HMDP 骨シンチ甲状腺癌

项目摘要

Bone metastases from differentiated thyroid carcinoma (DTC) are sometimes difficult to visualize on bone X-ray films. Conventional Tc-99m-diphosphonates bone scintigraphy (CBS) IS used for detecting bone metastases of DTC. 18F-NaF has been used in PET as a bone seeking agent. We evaluated the effectiveness of NaF-PET in comparison with CBS for the diagnosis of bone metastases in DTC. Diagnostic abilities of F-18 NaF-PET and CBS were examined visually based on the following criteria : ability to distinguish lesions from normal bone structure ; visual resolution ; and ability to distinguish uptake metastases and osteoarthritis in the ROIs. The overall accuracy of bone PET was higher in all subjects. CBS was accurate in distinguishing lesions from normal bone. but did not perform well in the other two criteria. Quantitative evaluation of the ratio of normal to metastatic bone was significantly different in PET studies but not in CBS studies of osteoarthritis.

分化型甲状腺癌（DTC）的骨转移有时很难在骨x线片上看到。常规tc -99m-二膦酸盐骨显像（CBS）用于检测DTC骨转移。18F-NaF在PET中作为寻骨剂使用。我们比较了NaF-PET与CBS在诊断DTC骨转移中的有效性。F-18 NaF-PET和CBS的诊断能力根据以下标准进行视觉检查：区分病变与正常骨结构的能力；视觉分辨率；以及在roi中区分摄取转移和骨关节炎的能力。骨PET的总体准确性在所有受试者中都较高。CBS在区分病变和正常骨方面是准确的。但在其他两个标准中表现不佳。正常骨与转移骨比例的定量评估在PET研究中有显著差异，但在骨关节炎的CBS研究中无显著差异。