Non-invasive estimation of human iron load and its clinical application using T2* and T2 maps calculated from MR imaging

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Newly developed T2* and T2 maps were clinically applied to patients with chronic liver diseases. As liver dysfunction progresses, T2* and T2 values of the liver decreased, representing intrinsic iron deposit. After SPIO, ΔT2*and ΔT2 also reduced, representing Kupffer cell dysfunction. Splenic signals were also correlated to liver dysfunction level. T2* and T2 maps were useful in assessing hepatosplenic condition in patients with chronic liver disease.