Individualized radiotherapy with molecular imaging of tumor

在本研究中，我们评估了(1)小鼠肿瘤的放射敏感性与β&lt；62&gt；铜-ATSM蓄积的相关性，(2)宫颈癌患者MetAP2过表达与Metionine PET的相关性，(3)基于^&lt；62&gt；铜-ATSM PET的乏氧肿瘤治疗计划模拟模型，(4)应用微阵列分析检测生物标记物对宫颈癌患者预后的影响。结果表明，放射敏感性与肿瘤组织中β-ATSM的蓄积有关，分子成像在碳离子放射治疗中具有较高的疗效。

In the present study, we evaluated (1) the correlation between radiosensitivities of murine tumor and accumulation of ^<62>Cu-ATSM, (2) the correlation of MetAP2 overexpression and Metionine PET in uterine cervical cancer patients, (3) Simulation model of ^<62>Cu-ATSM PET based treatment planning for hypoxic tumors, (4) detection of biomarker by using microarray analysis in relation to prognosis of cervical cancer patients. The results indicated radiosensitivity correlated with the accumulation of ^<62>Cu-ATSM in the tumor, and molecular imaging is highly effective in the treatment with carbon ion radiotherapy.