Novel therapeutic target for regulation of inflammation in tumor microenvironment

调节肿瘤微环境炎症的新治疗靶点

• 批准号: 19591493
• 负责人: IWAHASHI Makoto
• 金额: $ 2.41万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591493/
• 关键词: 外科総論; 胃癌; IL-17; IL-21; 炎症; 血管新生; 癌浸潤; 癌; 外科; 免疫; 遺伝子; サイトカイン

Expression of IL-17, IL-21 and IL-23 mRNA was found to be significantly up-regulated in tumor tissues compared with adjacent normal tissues. The expression level of IL-17 mRNA correlated with that of IL-21 and IL-23 mRNA in tumor tissue. The expression level of IL-17 mRNA in gastric tumors was associated with the depth of the tumors, suggesting that IL-17 obviously was related to tumor progression.

IL-17、IL-21和IL-23 mRNA在肿瘤组织中的表达较癌旁正常组织明显上调。肿瘤组织中IL-17 mRNA的表达水平与IL-21和IL-23 mRNA的表达水平相关。胃癌组织中IL-17 mRNA的表达水平与肿瘤的深度有关，提示IL-17与肿瘤的进展有明显的相关性。

项目成果

Tumor-infiltrating CD4^+ T cells secreting IL-17 Th17 promotes tumor growth in humangastric cancer

分泌IL-17 Th17的肿瘤浸润CD4^T细胞促进人胃癌肿瘤生长

• 发表时间: 2009
• 作者: Tabata A;Morikawa M;Miyajima M;Bennett BL;Satoh Y;Huang J;Tamura Y;Sato N;Abe T.;Ojima Toshiyasu;Tabata A;Ojima Toshiyasu;Sakata K;Kurose M;飯田武;飯田武
• 通讯作者: 飯田武

Dendritic cells with transduced survivin gene induce specific cytotoxic T lymphocytes in human urologic cancer cell lines.

• DOI: 10.1016/j.urology.2008.12.045
• 发表时间: 2009-07
• 期刊: Urology
• 影响因子: 2.1
• 作者: K. Kikkawa;Reona Fujii;Tomomi Kuramoto;Takashi Mori;T. Inagaki;Y. Kohjimoto;M. Iwahashi;H. Yamaue;I. Hara

Benefits of gene transduction of granulocyte macrophage colony-stimulating factor in cancer vaccine using genetically modified dendritic cells.

使用转基因树突状细胞在癌症疫苗中进行粒细胞巨噬细胞集落刺激因子基因转导的好处。

• 发表时间: 2008
• 期刊: Int J Oncol 31(4)
• 作者: Ojima T;et. al.;Koga K.et al.;Naka Teiji;Ojima Toshiyasu;Ojima Toshiyasu
• 通讯作者: Ojima Toshiyasu

Bacillus Calmette-Guerin cell-wall skeleton enhances the killing activity of cytotoxic lymphocyte-activated human dendritic cells transduced with the prostate-specific antigen gene

• DOI: 10.1111/j.1464-410x.2009.08703.x
• 发表时间: 2009-12-01
• 期刊: BJU INTERNATIONAL
• 影响因子: 4.5
• 作者: Fujii, Reona;Iwahashi, Makoto;Hara, Isao
• 通讯作者: Hara, Isao

Distribution of regulatory T cells in tumor draining lympho node in patients with gastric cancer.

胃癌患者肿瘤引流淋巴结中调节性T细胞的分布。

• 发表时间: 2007
• 作者: 長島勉;その;他;飯田武
• 通讯作者: 飯田武