The impact of hyperinsulinemia and tuberin in the development of hepatocellular carcinoma
The impact of hyperinsulinemia and tuberin in the development of hepatocellular carcinoma
批准号:
19790643
负责人:
KAWAGUCHI Takumi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
高胰岛素血症常见于肝细胞癌(HCC)患者。由于胰岛素是一种促进生长的激素,高胰岛素血症可能与HCC的发生有关。在这项研究中,我们发现胰岛素可能通过激活与细胞增殖相关的细胞内分子与HCC的发生有关。
英文摘要
Hyperinsulinemia is frequently seen in patients with hepatocellularcarcinoma (HCC). Since insulin is a growth-promoting hormone, hyperinsulinemia may beinvolved in the development of HCC. In this study, we reveled that insulin may associate with the development of HCC though activation of intracellular molecules related to cell proliferation.
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Body cell mass is a useful parameter for assessing malnutrition and severity of disease in non-ascitic cirrhotic patients with hepatocellular car cinoma or esophageal varices
体细胞量是评估患有肝细胞癌或食管静脉曲张的非腹水性肝硬化患者营养不良和疾病严重程度的有用参数
DOI:
--
发表时间:
2008
期刊:
Int J Mol Med 22
影响因子:
--
作者:
[Kawaguchi T, et.al.]
通讯作者:
et.al.
Supplement improves nutrition and stresses caused by examination‐associated fasting in patients with liver cirrhosis
补充剂可改善肝硬化患者因检查禁食而造成的营养和压力
DOI:
10.1111/j.1872-034x.2008.00390.x
发表时间:
2008
期刊:
Hepatology Research
影响因子:
4.2
作者:
[T. Kawaguchi, E. Taniguchi, M. Itou, Michiko Mutou, Ryoko Ibi, Satomi Shiraishi, Teruyo Okada, Yuki Uchida, Momoka Otsuka, Tatsuyuki Tonan, K. Fujimoto, T. Oriishi, Suiko Tanaka, Machiko Takakura, M. Sata]
通讯作者:
M. Sata
USE OF EXOGENOUS INSULIN OR SULFONYLUREA ASSOCIATED WITH AN INCREASED INCIDENCE OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH HEPATITIS C VIRUS INFECTION
使用外源性胰岛素或磺酰脲类药物会增加丙型肝炎病毒感染患者的肝细胞癌发病率
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[曽根正勝, 中尾一和, Kawaguchi T et al.]
通讯作者:
Kawaguchi T et al.
DOI:
10.1111/j.1440-1746.2007.05183.x
发表时间:
2008-02-01
期刊:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
影响因子:
4.1
作者:
[Itou, Minoru, Kawaguchi, Takumi, Sata, Michio]
通讯作者:
Sata, Michio
DOI:
10.2353/ajpath.2010.090242
发表时间:
2010-01-01
期刊:
AMERICAN JOURNAL OF PATHOLOGY
影响因子:
6
作者:
[Kawaguchi, Takumi, Yamagishi, Sho-ichi, Sata, Michio]
通讯作者:
Sata, Michio
共 15 条
The cytobiological impact of insulin resistance on BMPs-related epithelial-mesenchymal transition of hepatocellular carcinoma
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批准号:22790874
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.5万
-
财政年份:2010
-
负责人:KAWAGUCHI Takumi
-
依托单位:
BIOLOGICAL ROLES OF NEW TRANSCRIPTION FACTOR FOR GLUCOSE METABOLISM(ChREBP) IN PANCREATIC ISLET CELLS
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批准号:15590963
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
-
财政年份:2003
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负责人:KAWAGUCHI Takumi
-
依托单位:
海外基金