The impact of hyperinsulinemia and tuberin in the development of hepatocellular carcinoma

高胰岛素血症和马铃薯素在肝细胞癌发生发展中的影响

• 批准号: 19790643
• 负责人: KAWAGUCHI Takumi
• 金额: $ 2.41万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790643/
• 关键词: 糖尿病学; 肝細胞癌; インスリン抵抗性; tuberin; mTOR; 細胞増殖; インスリン情報伝達経路; HOMA-IR; 2型糖尿病; インスリン; mammalian target of rapamycin; insulin receptor substrate 1; Akt; 結節性硬化症

Hyperinsulinemia is frequently seen in patients with hepatocellularcarcinoma (HCC). Since insulin is a growth-promoting hormone, hyperinsulinemia may beinvolved in the development of HCC. In this study, we reveled that insulin may associate with the development of HCC though activation of intracellular molecules related to cell proliferation.

高胰岛素血症常见于肝细胞癌患者。由于胰岛素是一种促生长激素，高胰岛素血症可能参与了肝细胞癌的发生发展。在这项研究中，我们揭示了胰岛素可能通过激活与细胞增殖相关的细胞内分子而与肝癌的发生发展有关。

项目成果

Body cell mass is a useful parameter for assessing malnutrition and severity of disease in non-ascitic cirrhotic patients with hepatocellular car cinoma or esophageal varices

体细胞量是评估患有肝细胞癌或食管静脉曲张的非腹水性肝硬化患者营养不良和疾病严重程度的有用参数

• 发表时间: 2008
• 期刊: Int J Mol Med 22
• 作者: Kawaguchi T;et.al.
• 通讯作者: et.al.

Supplement improves nutrition and stresses caused by examination‐associated fasting in patients with liver cirrhosis

补充剂可改善肝硬化患者因检查禁食而造成的营养和压力

• DOI: 10.1111/j.1872-034x.2008.00390.x
• 发表时间: 2008
• 期刊: Hepatology Research
• 影响因子: 4.2
• 作者: T. Kawaguchi;E. Taniguchi;M. Itou;Michiko Mutou;Ryoko Ibi;Satomi Shiraishi;Teruyo Okada;Yuki Uchida;Momoka Otsuka;Tatsuyuki Tonan;K. Fujimoto;T. Oriishi;Suiko Tanaka;Machiko Takakura;M. Sata
• 通讯作者: M. Sata

USE OF EXOGENOUS INSULIN OR SULFONYLUREA ASSOCIATED WITH AN INCREASED INCIDENCE OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH HEPATITIS C VIRUS INFECTION

使用外源性胰岛素或磺酰脲类药物会增加丙型肝炎病毒感染患者的肝细胞癌发病率

• 发表时间: 2009
• 作者: 曽根正勝;中尾一和;Kawaguchi T et al.
• 通讯作者: Kawaguchi T et al.

Pigment Epithelium-Derived Factor Inhibits Lysosomal Degradation of Bcl-xL and Apoptosis in HepG2 cells

• DOI: 10.2353/ajpath.2010.090242
• 发表时间: 2010-01-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Kawaguchi, Takumi;Yamagishi, Sho-ichi;Sata, Michio
• 通讯作者: Sata, Michio

Altered expression of glucagon-like peptide-1 and dipeptidyl peptidase IV in patients with HCV-related glucose intolerance

• DOI: 10.1111/j.1440-1746.2007.05183.x
• 发表时间: 2008-02-01
• 期刊: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
• 影响因子: 4.1
• 作者: Itou, Minoru;Kawaguchi, Takumi;Sata, Michio
• 通讯作者: Sata, Michio