Investigation of the mechanism of food allergy development on germ free mice and the approach to therapy

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A failure of oral tolerance induction leads to susceptibility to food antigens. When oral tolerance was induced in either SPF or GF mice, oral tolerance was successfully induced in SPF mice, but not in GF mice. One of mechanisms by which oral tolerance could not be induced in GF mice was attributed to impaired number and function of CD25+CD4+ regulatory T cell in GALT of GF mice. Indigenous microbiota were thus considered to contribute to the induction and maintenance of CD25+CD4+ regulatory T cell in GALT.