An artificial placenta using a sheep model

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Our purpose was to develop an artificial placenta in a form of a pumpless arteriovenous extracorporeal life support circuit, in which infant's own blood pressure droved the system. In an animal experiment using the chronically instrumented fetal sheep, we could demonstrate that this system could support gas exchange and maintain fetal circulation for 15~30 hours. Prolonged support assured cerebral oxygen delivery would require a parallel circuit based on a low resistance oxygenator.