Research on development of hyper IgE and dermatitis through Ttc7, the regulatory factor of an autoinflammatory disease

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Sufficient results have not been obtained by in vivo and ex vivo experiments using fsn mice, owing to MHV pollution in the SPF areas of the Wakayama Medical University Animal Facilities. Backcrossing BALB/c-fsn mice with C57BL/6 mice has been performed without revealing any obvious phenotype. On the other hand, the SNP analyses on human chronic dermatitis have shown a weak but significant association of a particular haplotype of the Ttc7a gene with psoriasis, rather than atopic dermatitis.