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The effect of fasudil, a Rho-kinase inhibitor, on cerebral microcirculation under total transient cerebral ischemia in rabbits.

Rho激酶抑制剂法舒地尔对兔短暂性脑缺血状态下脑微循环的影响。

基本信息

批准号：
19791061
负责人：
NAGASE Kiyoshi
金额：
$ 2.35万
依托单位：
Gifu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2007
资助国家：
日本
起止时间：
2007 至 2009
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791061/
关键词：
ファスジル頭窓法脳微小循環ネックターニケット

项目摘要

We studied the effect of fasudil, a Rho-kinase inhibitor, on cerebral microcirculation under total transient cerebral ischemia in rabbits. Cranial window was made on a temporal bone of Japanese White Rabbits with neck tourniquet to induce transient global cerebral ischemia. We observed cerebral pial arteioles' physiological changes induced by increased arterial carbon dioxide tension and the concentration of isoflurane, a volatile anesthetic. Fasudil did not change the degree of response either before or after cerebral ischemia, which we failed to observe cerebral arteriovasodilation by CO2 and isoflurane after ischemia. Furthermore, fasudil did not alter the response of cerebaral arterioles to CO2 and isoflurane under mild hypothermia. We concluded that fasudil itself did not impact on physiologic changes of cerebral microcirculation.

本文研究了Rho激酶抑制剂法舒地尔对家兔全脑缺血时脑微循环的影响。日本白色家兔颞骨上制作颅窗，颈部止血带，诱导短暂性全脑缺血。本文观察了动脉二氧化碳分压升高和吸入麻醉药异氟醚浓度增加对软脑膜动脉的生理变化。法舒地尔在脑缺血前后均不改变反应程度，我们未能观察到缺血后CO2和异氟醚对脑血管的舒张作用。此外，法舒地尔并没有改变大脑小动脉对CO2和异氟醚的反应在亚低温。结论：法舒地尔本身对脑微循环的生理变化无影响。