The effect of fasudil, a Rho-kinase inhibitor, on cerebral microcirculation under total transient cerebral ischemia in rabbits.

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We studied the effect of fasudil, a Rho-kinase inhibitor, on cerebral microcirculation under total transient cerebral ischemia in rabbits. Cranial window was made on a temporal bone of Japanese White Rabbits with neck tourniquet to induce transient global cerebral ischemia. We observed cerebral pial arteioles' physiological changes induced by increased arterial carbon dioxide tension and the concentration of isoflurane, a volatile anesthetic. Fasudil did not change the degree of response either before or after cerebral ischemia, which we failed to observe cerebral arteriovasodilation by CO2 and isoflurane after ischemia. Furthermore, fasudil did not alter the response of cerebaral arterioles to CO2 and isoflurane under mild hypothermia. We concluded that fasudil itself did not impact on physiologic changes of cerebral microcirculation.