New drug delivery into inner ear ; possibility of the treatment withnano technology

新药物输送至内耳；

• 批准号: 19791184
• 负责人: YAMAUCHI Daisuke
• 金额: $ 2.37万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791184/
• 关键词: 耳鼻咽喉科学; ナノバイオ; nano particle(Qdot); drug delivery system; inner ear; cochlear nucleus; nano particle (Qdot)

Nano particle was examined for the potential of drug delivery to inner ear. Qdot 655 was conjugated respectively with several peptides which are horseradish peroxidase(HRP), Galectin-1, L-Glutamin Acid and epidermal growth factor(EGF). When Qdot was injected into scala media of the cochlea in guinea pig, Qdots with Galectin 1 and EGF were introduced into organ of Corti and Reissner's membrane. Nano particle is expected as treatment for inner ear disease.

研究了纳米颗粒内耳给药的潜力。Qdot 655分别与辣根过氧化物酶（HRP）、半乳糖凝集素-1、l -谷氨酰胺酸和表皮生长因子（EGF）等多肽偶联。将Qdot注射到豚鼠耳蜗基质中，将Qdot与凝集素1和EGF一起引入Corti膜和Reissner膜器官。纳米粒子有望成为内耳疾病的治疗手段。