Basic science research for regenerative treatment of olfactory dysfunction by head injury

头部损伤嗅觉功能障碍再生治疗的基础科学研究

• 批准号: 19791204
• 负责人: MASAYOSHI Kobayashi
• 金额: $ 2.36万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791204/
• 关键词: 嗅覚; 再生; 外傷; マウス; 神経; 嗅神経; 切断

The present study wad designed to investigate if replacing the cribriform plate with fascia can facilitate olfactory nerve recovery after olfactory nerve transection. Areas of injury-associated tissue were significantly smaller in the mild injury model, and at 42 days the regenerated nerves had reestablished connections to the glomerular layer of the bulb. With severe injury, there were larger areas of injury-associated tissue, more astrocytes and macrophages, and a decrease in regenerated nerve fibers. When dexamethasone (DXM) was injected after severe injury, there was a significant reduction in injury-associated tissue, better nerve recovery and fewer astrocytes and macrophages. These results demonstrate that recovery in the olfactory system varies with the severity of injury, and that DXM treatment may have therapeutic value by reducing injury-associated tissue and improving recovery outcome.

本研究旨在探讨用筋膜代替筛网板是否能促进嗅神经断裂后的嗅觉神经恢复。在轻度损伤模型中，损伤相关组织的面积明显变小，并且在42天再生的神经已经重建了与球的肾小球层的连接。损伤严重时，损伤相关组织面积增大，星形胶质细胞和巨噬细胞增多，再生神经纤维减少。严重损伤后注射地塞米松（dexamethasone， DXM），损伤相关组织明显减少，神经恢复较好，星形胶质细胞和巨噬细胞减少。这些结果表明，嗅觉系统的恢复随损伤的严重程度而变化，并且DXM治疗可能通过减少损伤相关组织和改善恢复结果而具有治疗价值。

项目成果

嗅覚研究の臨床医学応用

嗅觉研究的临床医学应用

• 发表时间: 2010
• 期刊: におい・かおり環境学会誌 41
• 作者: 小林正佳;小林正佳
• 通讯作者: 小林正佳

外傷性嗅覚障害の予後改善のための基礎研究

改善创伤性嗅觉丧失预后的基础研究

• 发表时间: 2008
• 作者: Nakaya M;et. al.;小林正佳;小林正佳
• 通讯作者: 小林正佳

総説特集I:嗅覚臨床研究の進歩-6:外傷性嗅覚障害の予後改善のための研究

综述专题一：临床嗅觉研究进展之六：改善创伤性嗅觉丧失预后的研究

• 发表时间: 2009
• 期刊: 日本味と匂学会誌 16
• 作者: Masayoshi Kobayashi;Richard M. Costanzo;小林正佳
• 通讯作者: 小林正佳

外傷性嗅覚障害

外伤性嗅觉丧失

• 发表时间: 2014
• 作者: Shiga H;Taki J;Okuda K;Watanabe N;Tonami H;Kinuya S;Furukawa M;Miwa T.;志賀英明
• 通讯作者: 志賀英明

嗅覚障害の治療

嗅觉障碍的治疗

• 发表时间: 2010
• 期刊: MB ENT 117
• 作者: 小林正佳