Fluorous Chemistry: New tagging agents and heterocyclic-based fluorous surfactants

含氟化学：新型标记剂和杂环含氟表面活性剂

• 批准号: DP0346614
• 负责人: A/Prof Roger Read
• 金额: $ 17.07万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-03-24 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0346614
• 关键词: Fluorous; Chemistry; New; tagging; agents

Fluorous chemistry is emerging as a powerful adjunct to areas of conventional parallel and combinatorial organic syntheses, and its introduction has revolutionised separation technologies. In this project two new fluorous tagging strategies will be investigated in an effort to broaden the scope of reagents that can used in synthesis. Efforts will be directed to chiral auxiliaries and to fluorous catalyst ligands. In addition, a novel class of fluorous surfactant will be investigated, for its surface properties (including its ability to self assemble) and for its utility in two specific applications, selective membrane-bound protein extraction (relevant to proteomics) and ophthalmics (biomaterials).

氟化学正在成为传统的平行和组合有机合成领域的一个强大的辅助工具，它的引入使分离技术发生了革命性的变化。在这个项目中，将研究两种新的氟标记策略，以努力扩大可用于合成的试剂的范围。努力的方向将是手性助剂和氟催化剂配体。此外，还将研究一类新型氟表面活性剂的表面性质(包括自组装能力)以及它在两个特定应用中的应用：选择性膜结合蛋白提取(与蛋白质组学相关)和眼科(生物材料)。