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Self-Assembling Peptide Nanofiber Scaffolds, Platelet Rich Plasma, and Mesenchymal Stem Cells for Injectable Bone Regeneration with Tissue Engineering

自组装肽纳米纤维支架、富血小板血浆和间充质干细胞用于组织工程可注射骨再生

基本信息

批准号：
19791505
负责人：
KENJI Ito
金额：
$ 2.43万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2007
资助国家：
日本
起止时间：
2007 至 2009
项目状态：
已结题

项目摘要

The purpose of this study was to investigate a capability of 3D PuraMatrix^<TM> (PM), which is a self-assembling peptide nanomaterial, as a scaffold for bone regeneration in combination with dog mesenchymal stem cells (dMSCs) and/or platelet-rich plasma (PRP) using tissue engineering and regenerative medicine (TERM) technology. This report showed that MSCs might keep their own potential and promote new bone regeneration in the three-dimensional structure by PM scaffolds. Taken together, it is suggested that PM might be useful as a scaffold of bone regeneration in cell therapy, and these results might lead to an effective treatment method for bone defects.

本研究的目的是研究 3D PuraMatrix™ (PM)（一种自组装肽纳米材料）作为骨再生支架的能力，与狗间充质干细胞 (dMSC) 和/或富血小板血浆 (PRP) 结合使用组织工程和再生医学 (TERM) 技术。该报告表明，间充质干细胞可能会通过PM支架在三维结构中保持自身潜力并促进新骨再生。综上所述，PM可能可用作细胞治疗中骨再生的支架，这些结果可能会导致骨缺损的有效治疗方法。