Self-Assembling Peptide Nanofiber Scaffolds, Platelet Rich Plasma, and Mesenchymal Stem Cells for Injectable Bone Regeneration with Tissue Engineering

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The purpose of this study was to investigate a capability of 3D PuraMatrix^<TM> (PM), which is a self-assembling peptide nanomaterial, as a scaffold for bone regeneration in combination with dog mesenchymal stem cells (dMSCs) and/or platelet-rich plasma (PRP) using tissue engineering and regenerative medicine (TERM) technology. This report showed that MSCs might keep their own potential and promote new bone regeneration in the three-dimensional structure by PM scaffolds. Taken together, it is suggested that PM might be useful as a scaffold of bone regeneration in cell therapy, and these results might lead to an effective treatment method for bone defects.