The involvement of Ephrin signaling in the invasion and metastas is of squamous cell carcinoma cells

Eph/Ephrin mRNA和蛋白在口腔鳞癌（OSC）细胞中表达。EphrinB2在口腔鳞状细胞癌和高侵袭性OSC细胞中高表达。与对照细胞相比，EphrinB2敲除细胞的增殖、附着和侵袭均受到抑制。EphB/Fc嵌合体促进了附着，但抑制了EphrinB2敲除细胞的侵袭。这些结果表明EphrinB2参与OSC细胞的增殖、附着和侵袭。

Eph/Ephrin mRNA and protein were expressed in oral squamous cell carcinoma (OSC) cells. EphrinB2 was especially overexpressed in oral squamous cell carcinoma and high invasive OSC cells. The proliferation, attachment, and invasion were suppressed in EphrinB2 knock-downed cells as compared with control cells. The treatment with EphB/Fc chimera promoted the attachment, but inhibited the invasion of EphrinB2 knock-downed cells. these results suggest that EphrinB2 contributes to the proliferation, attachment, and invasion of OSC cells.