Control of nonlinear processes of protein solution and biological cells induced by focused femtosecond laser

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When an intense infrared-femtosecond-laser is focused into biological materials, shockwave and cavitation bubble are generated at the laser focal point, in which an explosive morphological change of water is induced by an effective multiphoton absorption. I developed a new local force measurement system to estimate the impulsive force due to the shockwave and cavitation bubble generated in biological materials and elucidated time and spatial evolution of these phenomena. On the basis of this knowledge, new control and measurement methods of single cell or intracellular protein were devised.