Manipulation of dietary essential fatty acid balance for lifestyle-related disease prevention

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We investigated the effect of dietary essential fatty acid balance (n-6/n-3) on lifestyle-related diseases. N-3 fatty acids suppressed adipogenesis whereas they promoted both myoblast and osteoblast differentiation. Dietary n-3 fatty acid such as fish oil has been shown to decrease serum triglyceride, cholesterol and insulin levels and abdominal fat weight but increase muscle weight in the mice. These results demonstrate that the increased intake of n-3 fatty acid has preventive effects on metabolic syndrome. On the basis of the results, we made Lipid Balance Guide and used it in the class of junior high school. The guide was a useful educational tool for understanding of lipid nutrition.