Development of functional molecules on the basis of design of novel Lewis acid catalysts

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We investigated some synthetic reactions catalyzed Lewis acids. As novel Lewis acidic complexes, aluminum methide and silyl methide were developed. These complexes nicely catalyze the C-C bond forming reactions such as the Diels-Alder reaction and the Mukaiyama-Michael reaction. We also found that chemically stable, mild and soft Lewis acids are effective for the tandem azidation/1,3-dipolar cycloaddition reaction. By using this reaction, 1,2,3-triazole fused carbohydrate mimetics were easily synthesized.