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A basic research for phosphatidylinositol 3-kinase inhibitor utilization in lymphoma

A basic research for phosphatidylinositol 3-kinase inhibitor utilization in lymphoma
磷脂酰肌醇3激酶抑制剂在淋巴瘤中应用的基础研究
批准号:
19790273
负责人:
TAKEUCHI Kengo
金额:
$2.34万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
of the cases are accompanied by clinical information. In order to develop a biomarker analysis for PI3K pathway activation, we tried to immunostain the TMA slides for a phosphorylated substance X using various enhancement techniques. However, we failed to obtain a positive result. We also analyzed the methylation status of PTEN, which suppresses the PI3K pathway. Methylation-specific PCR revealed that the gene was methylated in 4 of 15 cases.
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DOI: 10.3727/096368909788809794
发表时间: 2009-01-01
期刊: CELL TRANSPLANTATION
影响因子: 3.3
作者: [Tanaka, Yujiro, Ikeda, Tamako, Hanazono, Yutaka]
通讯作者: Hanazono, Yutaka
DOI: 10.1016/j.lungcan.2010.01.001
发表时间: 2010-10-01
期刊: LUNG CANCER
影响因子: 5.3
作者: [Hiramatsu, Miyako, Ninomiya, Hironori, Ishikawa, Yuichi]
通讯作者: Ishikawa, Yuichi
DOI: 10.1158/1078-0432.ccr-08-3248
发表时间: 2009-05-01
期刊: CLINICAL CANCER RESEARCH
影响因子: 11.5
作者: [Takeuchi, Kengo, Choi, Young Lim, Mano, Hiroyuki]
通讯作者: Mano, Hiroyuki
DOI: 10.1002/ijc.24538
发表时间: 2009-10-15
期刊: INTERNATIONAL JOURNAL OF CANCER
影响因子: 6.4
作者: [Nakamura, Yu, Migita, Toshiro, Shibata, Tatsuhiro]
通讯作者: Shibata, Tatsuhiro
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