A basic research for phosphatidylinositol 3-kinase inhibitor utilization in lymphoma

磷脂酰肌醇3激酶抑制剂在淋巴瘤中应用的基础研究

• 批准号: 19790273
• 负责人: TAKEUCHI Kengo
• 金额: $ 2.34万
• 依托单位: Japanese Foundation For Cancer Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790273/
• 关键词: リンパ腫; PI3K; lymphoma

of the cases are accompanied by clinical information. In order to develop a biomarker analysis for PI3K pathway activation, we tried to immunostain the TMA slides for a phosphorylated substance X using various enhancement techniques. However, we failed to obtain a positive result. We also analyzed the methylation status of PTEN, which suppresses the PI3K pathway. Methylation-specific PCR revealed that the gene was methylated in 4 of 15 cases.

的个案附有临床资料。为了开发PI3K通路激活的生物标志物分析，我们尝试使用各种增强技术对TMA载玻片进行磷酸化物质X的免疫染色。然而，我们未能获得积极的结果。我们还分析了抑制PI3K通路的PTEN的甲基化状态。甲基化特异性PCR检测15例中4例基因甲基化。

项目成果

ERas Is Expressed in Primate Embryonic Stem Cells But Not Related to Tumorigenesis

• DOI: 10.3727/096368909788809794
• 发表时间: 2009-01-01
• 期刊: CELL TRANSPLANTATION
• 影响因子: 3.3
• 作者: Tanaka, Yujiro;Ikeda, Tamako;Hanazono, Yutaka
• 通讯作者: Hanazono, Yutaka

Activation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutations

• DOI: 10.1016/j.lungcan.2010.01.001
• 发表时间: 2010-10-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Hiramatsu, Miyako;Ninomiya, Hironori;Ishikawa, Yuichi
• 通讯作者: Ishikawa, Yuichi

KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer

• DOI: 10.1158/1078-0432.ccr-08-3248
• 发表时间: 2009-05-01
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Takeuchi, Kengo;Choi, Young Lim;Mano, Hiroyuki
• 通讯作者: Mano, Hiroyuki

Kruppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression

• DOI: 10.1002/ijc.24538
• 发表时间: 2009-10-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Nakamura, Yu;Migita, Toshiro;Shibata, Tatsuhiro
• 通讯作者: Shibata, Tatsuhiro

Frequent inactivation of A20 in B-cell lymphomas

• DOI: 10.1038/nature07969
• 发表时间: 2009-06-04
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Kato, Motohiro;Sanada, Masashi;Ogawa, Seishi
• 通讯作者: Ogawa, Seishi