Bach2による制御性T細胞の分化調節と肺動脈性肺高血圧症の関与

Bach2 对调节性 T 细胞分化的调节及其参与肺动脉高压

• 批准号: 17K09503
• 负责人: 土肥 由裕
• 金额: $ 3万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09503/
• 关键词: 肺高血圧症; 肺動脈性肺高血圧症; Bach2; 制御性T細胞

肺動脈性肺高血圧症の診断には右心カテーテル検査が必須である. スクリーニングに使用される心臓超音波検査では, 感度, 特異度ともに不十分である. ヒトPAHにおいてborder PH, non PH の群からPAH発症予測因子を同定するためには, PAHが発症したかどうかをより効率的に検出する必要があった. 我々は, 心肺運動負荷テストにおける呼気終末二酸化炭素分圧に注目して検討を行った. 結果, 心臓超音波検査における三尖弁圧較差と, 心肺運動負荷テストにおける呼気終末二酸化炭素分圧を併用することで, 感度, 特異度ともに十分な効率でPAHをdetectできることを報告した.また, これと平行して, まずはPAH症例の集約化を行った. 具体的には, 平成29年4月より平成31年3月までに, total 166例の肺高血圧症症例を当院に集約化した. 内訳は特発性肺動脈性肺高血圧症　21例, 遺伝性肺動脈性肺高血圧症　1例, 膠原病に伴う肺動脈性肺高血圧症　39例, 先天性心疾患に伴う肺動脈性肺高血圧症　12例, 肺静脈閉塞症　5例, 肺疾患に伴う肺高血圧症　13例, 左心疾患に伴う肺高血圧症 1例, 遺伝性出血性毛細血管拡張症に伴う肺高血圧症　1例, HIV感染に伴う肺動脈性肺高血圧症　1例, 慢性血液透析に伴う肺高血圧症　3例, 薬剤性肺動脈性肺高血圧症　7例, 慢性血栓塞栓性肺高血圧症　62例であった. 膠原病に伴う肺動脈性肺高血圧症のみの解析では, 症例数が不十分であり, 今後の解析はこれら全ての症例を対象として行う方針としていた.

Diagnosis of pulmonary arterial hypertensive syndrome requires the use of ultrasound examination of the right heart, sensitivity, Specificity is not very good. PAH border PH, non PH PAH syndrome predictive factor するためには, PAH が発 syndrome is necessary for efficiency. Cardiopulmonary exercise load is a good test of cardiopulmonary exercise load. As a result, the cardiac ultrasound examination showed poor tricuspid pressure, and the cardiopulmonary exercise load test showed that the terminal dicarboxylic acid carbonate separation pressure was used in combination, and the sensitivity was, Specificity is very high, efficiency is very high, PAH is detectable, report is reported, and PAH cases are intensified. Specifically, from April 2012 to March 2011, a total of 166 cases of pulmonary hypertension were admitted to the intensive care unit. There were 21 cases of idiopathic pulmonary arterial hypertension in the hospital. There was 1 case of hereditary pulmonary hypertension, 39 cases of collagen disease and pulmonary hypertension, 12 cases of congenital heart disease and pulmonary hypertension, 5 cases of pulmonary veno-occlusive disease, 13 cases of pulmonary disease and pulmonary hypertension. One case of left heart disease was accompanied by pulmonary hypertension, one case of hereditary hemorrhagic capillary dilatation was accompanied by pulmonary hypertension, one case of HIV infection was accompanied by pulmonary hypertension, and three cases of chronic hemodialysis were accompanied by pulmonary hypertension. There were 7 cases of pulmonary arterial hypertension and 62 cases of chronic thromboembolic pulmonary hypertension. Collagen disease is accompanied by pulmonary hypertension. The analysis of pulmonary hypertension is not complete. The number of cases is not very clear. In the future, the analysis will be based on the symptoms and symptoms of the disease and the policy and policy for the future.

项目成果

Right heart system is potent predictor in the pulmonary hypertension due to left heart disease patients with preserved ejection fraction.

右心系统是射血分数保留的左心疾病患者发生肺动脉高压的有效预测因子。

• 发表时间: 2018
• 作者: Suichi Tomoki;Misawa Sonoko;Sato Yasunori;Beppu Minako;Sakaida Emiko;Sekiguchi Yukari;Shibuya Kazumoto;Watanabe Keisuke;Amino Hiroshi;Kuwabara Satoshi;Yoshihiro Dohi;土肥 由裕
• 通讯作者: 土肥 由裕

Use of the augmentation index from applanation tonometry of the radial artery for assessing the extent of coronary artery calcium as assessed by coronary computed tomography

使用桡动脉压平张力测量的增强指数来评估通过冠状动脉计算机断层扫描评估的冠状动脉钙化程度

• DOI: 10.1080/10641963.2016.1267195
• 发表时间: 2017
• 期刊: Clinical and Experimental Hypertension
• 影响因子: 12.3
• 作者: Watanabe Noriaki;Kurisu Satoshi;Sumimoto Yoji;Ikenaga Hiroki;Shimonaga Takashi;Higaki Tadanao;Tatsugami Fuminari;Ishibashi Ken;Kitagawa Toshiro;Dohi Yoshihiro;Fukuda Yukihiro;Yamamoto Hideya;Awai Kazuo;Kihara Yasuki
• 通讯作者: Kihara Yasuki

左心系疾患に伴う肺高血圧症にPAH治療薬が有効か？

PAH 药物对左心病相关肺动脉高压有效吗？

• 发表时间: 2017
• 作者: 土肥 由裕;木原 康樹;他
• 通讯作者: 他

重症肺動脈性肺高血圧症の治療方針 ～初期診断と治療反応性評価の重要性～

重度肺动脉高压的治疗政策 - 早期诊断和评估治疗反应的重要性 -

• 发表时间: 2018
• 作者: Shibuya K;Tsuneyama A;Beppu M;Misawa S;Sekiguchi Y;Amino H;Suzuki YI;Suichi T;Nakamura K;Kuwabara S;土肥 由裕
• 通讯作者: 土肥 由裕

Evaluation of end-tidal CO2 pressure at the anaerobic threshold for detecting and assessing pulmonary hypertension

• DOI: 10.1007/s00380-017-0999-y
• 发表时间: 2017-11-01
• 期刊: HEART AND VESSELS
• 影响因子: 1.5
• 作者: Higashi, Akifumi;Dohi, Yoshihiro;Kihara, Yasuki
• 通讯作者: Kihara, Yasuki