Application of hydrogels for adhesion prevention after thoracotomy

交联聚（γ-谷氨酸）（PGAXL）是一种能够形成水凝胶的生物可降解聚合物。在本研究中，我们使用开胸手术的小鼠模型，研究局部应用PGAXL是否可以减弱开胸手术部位的粘连形成。我们发现，局部应用PGAXL可减弱开胸手术部位肺与壁胸膜之间以及胸壁与胸肌之间的粘连形成。

Cross-linked poly (gamma-glutamic acid) (PGAXL) is a biodegradable polymer capable of forming a hydrogel. In the present study, using a mouse model of thoracotomy, we investigated whether local application of PGAXL could attenuate adhesion formation at the thoracotomy site. We found that local application of PGAXL attenuated adhesion formation at the site of thoracotomy between the lung and the parietal pleura as well as between the chest wall and the chest muscles..