Elucidation of the role of intramedullary microcirculation in the pathogenesis of syringomyelia and the possibility of a new treatment

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Pathogenesis of syringomyelia was studied using experimental models and radiological analysis of clinical cases. The results indicate that the dynamics of extracellular fluid and intramedullary microcirculation plays an important role in development of syringomyelia. In syringomyelia, the increased extracellular fluid state was present around the central canal and the syrinx and spread centrifugally. Such interstitial edema disappeared after treatment of the syrinx. Disturbed absorption of the extracellular fluid through the intramedullary venous system will be the primary mechanism in the pathogenesis of syringomyelia.