Expression of SOX4 gene and its roles in medulloblastoma

我们分析了Sox4 mRNA的表达在各种脑肿瘤手术切除或肿瘤细胞系，使用实时PCR分析。我们发现Sox 4 mRNA在髓母细胞瘤中的表达水平在这些脑肿瘤中尤其增加。将Sox 4基因导入恶性胶质瘤细胞系后，细胞生长明显增强。相反，当我们将Sox 4基因转移到髓母细胞瘤细胞系中时，细胞生长没有显着变化。

We analyzed the expression of Sox4 mRNA in various brain tumor samples obtained by surgical resection or tumor cell lines using real-time PCR analysis. We found that the expression levels of Sox4 mRNA in medulloblastomas are especially increased among these brain tumors. When we transfer Sox4 gene into malignant glioma cell lines, the cell growth was strongly enhanced. Conversely, when we transfer Sox4 gene into medulloblastoma cell lines, there was no significant change in cell growth.